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Severe functional limitations are reported among children with microcephaly and laboratory evidence of Zika virus infection in infancy

Functional Limitations Ongoing With Congenital Zika

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All 19 children reported one of six adverse outcomes; 12 had three to five outcomes at 19 to 24 months
The U.S. Centers for Disease Control and Prevention has updated its interim guidance for U.S. health care providers caring for infants with possible congenital Zika virus infection

CDC Updates Zika Guidance for Infant Care

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Recommendations include evaluation and management of infants with possible infection
The cobas Zika test has been approved by the U.S. Food and Drug Administration -- the first approved screening test to detect the Zika virus in blood donations.

First Test to Detect Zika in Blood Donations Approved

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Not designed to diagnose the infection, however
A single mutation in the Zika virus made it more virulent

Single Mutation Made Zika Virus More Virulent

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This viral polyprotein mutation increases microcephaly, mortality in mouse models
A rapid immunochromatography approach can differentiate dengue virus and Zika virus cases

Immunochromatography Testing Differentiates Dengue, Zika

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Serum ZIKV NS1 protein concentrations are 10-fold lower than corresponding DENV NS1 concentrations
Certain ocular histopathologic features are consistently found in fetuses with congenital Zika syndrome

Ocular Histopathology Features Seen With Congenital Zika

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Features include loss of retinal pigment epithelium, presence of a thin choroid
Zika virus is an oncolytic virus that preferentially targets glioblastoma stem cells

Zika Virus Preferentially Targets Glioblastoma Stem Cells

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ZIKV preferentially infects, kills GSCs relative to differentiated tumor progeny, normal neuronal cells
Retinal maldevelopment associated with congenital Zika syndrome is similar to the maldevelopment seen with cobalamin C deficiency

Zika, Cobalamin C Deficiency Tied to Similar Retinal Problems

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Congenital Zika syndrome associated with severe ganglion cell layer loss, thinning of central retina
The Zika virus thrives in pregnant women by suppressing their already dampened immune systems and running roughshod over their body's natural defenses

Zika Thrives in Pregnancy Due to Vulnerable Immune System

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Study demonstrates effects of infection with different lineages of Zika virus on monocytes
The Zika virus might not remain in the semen of some infected men as long as previously thought

Zika Does Not Appear to Last in Semen As Long As Thought

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More research is needed to better inform public health recommendations