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Most children with Zika virus infection have fever

Fever, Rash, Erythema Seen in Most Puerto Rican Kids With Zika

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Median serum viral load varies significantly according to number of days after symptom onset
Screening blood donations for Zika virus in the United States is costly with low yield

Screening Blood Donations for Zika Virus Is Costly, Low Yield

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Nine donations were confirmed positive; six of these had travelled to ZIKV-active areas
Zika virus (ZIKV) RNA is frequently present in the semen of men with symptomatic ZIKV infection and can persist for over six months

ZIKV RNA Often ID’d in Semen of Men With Symptomatic Infection

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Drop in ZIKV RNA shedding in semen seen within 3 months after illness onset but can persist longer
A Zika vaccine could substantially prevent future outbreaks through a combination of direct protection and indirect transmission reduction

Zika Vaccine Could Essentially Eliminate Prenatal Infection

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Model shows vaccine is effective through a combo of direct protection, indirect transmission reduction
Seven percent of pregnant women with symptomatic Zika virus infection have birth defects possibly associated with Zika virus infection

Zika-Tied Birth Defects in 7 Percent of Infected Pregnant Women

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Defects occurred more frequently when Zika virus infection occurred in the first trimester
A total of 5

Over 5,100 Noncongenital Zika Cases Reported in U.S. in 2016

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Ninety-five percent of cases were identified in travelers returning from Zika virus-affected areas
Zika virus infection seems to be associated with uteroplacental pathology and may affect oxygen transport within the placenta in pregnant rhesus macaques

Zika Virus Infection Linked to Uteroplacental Pathology

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ZIKV infection causes placental inflammation and decreases oxygen reserve, oxygen permeability
Emerging neurotropic flaviviruses related to Zika virus (ZIKV) may share ZIKV's capacity for transplacental transmission

Zika-Related Flaviviruses May Cause Congenital Infection

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West Nile, Powassan viruses infect placenta and nervous system, harming developing brain in mice
From the first half of 2016 to the second half of 2016

2016 Saw Increase in Birth Defects Potentially Linked to Zika

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From first to second half of 2016, increase in number of birth defects potentially related to Zika
Type 1 interferons may mediate pregnancy complications in the context of congenital Zika virus infection

Type 1 IFNs May Mediate Zika Pregnancy Complications

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After Zika virus infection, IFNAR signaling in conceptus inhibits development of placental labyrinth