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Tag: Vaginal Problems

Vulvar and vaginal melanomas have unique molecular features as compared to nongynecologic melanoma

Unique Molecular Features for Vulvar, Vaginal Melanomas

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BRAF most frequently mutated gene in VVMs, while NRAS mutations are rarely seen
Intrarosa (prasterone) has been approved by the U.S. Food and Drug Administration to treat women who have moderate-to-severe pain during sexual intercourse caused by postmenopausal vulvar and vaginal atrophy.

FDA Approves Intrarosa for Postmenopausal Pain During Sex

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Drug contained in a once-daily vaginal insert
For postmenopausal women with early-stage breast cancer taking aromatase inhibitors

Intravaginal Testosterone Deemed Safe in Early Breast CA

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Findings in postmenopausal women with early-stage breast cancer receiving aromatase inhibitors
For pregnant women

Oral Probiotics Have No Impact on Vaginal Health in Pregnancy

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Similar decrease in proportion of normal vaginal microbiota for treatment, placebo groups
Women with vaginal mesh with complications have a significantly increased proinflammatory response

Proinflammatory Response in Women With Vaginal Mesh

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Significantly higher M1/M2 cytokines, chemokines, MMP-9 and -2 in women with mesh-vagina explants
Women with vaginal mesh with complications have a significantly increased proinflammatory response

Proinflammatory Response in Women With Vaginal Mesh

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Significantly higher M1/M2 cytokines, chemokines, MMP-9 and -2 in women with mesh-vagina explants
For women with symptomatic pelvic organ prolapse

Vaginal Pessary Beneficial in Pelvic Organ Prolapse

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Improvements in prolapse symptoms and quality of life with pessary added to pelvic floor exercises
For women undergoing mesh-based prolapse surgery

Reoperation Rate 4 Percent for Mesh-Based Prolapse Surgery

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Risk of reoperation was lowest for patients of very high-volume surgeons
Use of vaginal estrogen should be carefully considered by women with a history of estrogen-dependent breast cancer

ACOG: Vaginal Estrogen Can Be Used for Breast Cancer Survivors

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Decision to use vaginal estrogen should be made with oncologist, after consideration of data
For women with vaginal prolapse

Review: Risks and Benefits for Transvaginal Mesh

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Lower rates of awareness of prolapse, reoperation for prolapse; higher rates of de novo incontinence