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Guidelines have been updated for screening and treatment for tuberculosis infection among health care personnel

Recs Updated for TB Screening, Treatment in Health Care Workers

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Guidelines include preplacement TB risk assessment, postexposure symptom evaluation and testing
In 2017

CDC: TB Incidence Declined Slightly in United States in 2017

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Number of cases, disease incidence decreased globally, but more progress needed to meet targets
For HIV-infected patients

One-Month Regimen Noninferior for Preventing HIV-Related TB

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One-month rifapentine, isoniazid noninferior to nine months of isoniazid alone
A short regimen is noninferior to a long regimen for patients with rifampin-resistant tuberculosis that is susceptible to fluoroquinolones and aminoglycosides

Short Regimen Noninferior for Rifampin-Resistant Tuberculosis

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Short regimen of nine to 11 months noninferior to 20-month regimen following WHO guidelines
Stratifying tuberculosis patients by disease severity may enable shorter treatment regimens

Stratifying by Severity May Allow Shorter TB Tx Regimens

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Those with minimal disease may be cured with a four-month versus six-month treatment regimen
The frequency of relapse-free cure from multidrug-resistant tuberculosis is higher than previously anticipated

Relapse-Free Cure From MDR-TB Higher Than Anticipated

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Per simplified outcome definition, frequency similar in low-, intermediate-, high-incidence countries
In pretreatment isolates of Mycobacterium tuberculosis

MICs of Isoniazid, Rifampin May Predict Tuberculosis Relapse

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Higher MIC in pretreatment M. tuberculosis isolates linked to relapse risk
In children with latent tuberculosis

Rifampin Effective for Latent Tuberculosis in Children

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Rifampin has advantage of being a shorter, single-drug regimen that is palatable for children
A four-month regimen of rifampin is similar to a nine-month regimen of isoniazid for the prevention of active tuberculosis

Rifampin Similar to Isoniazid for Preventing Active Tuberculosis

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Rifampin has significantly higher rate of treatment completion, fewer drug-related adverse events
Most people complete treatment for latent tuberculosis without direct observation

Completion Likely With Self-Administration of TB Treatment

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Self-administration without reminders is noninferior to direct observation in patients with latent TB