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Different racial/ethnic groups with multiple myeloma have significant variations in novel therapy and autologous stem cell transplant use

Use of Novel Therapy, Stem Cell Transplant in MM Varies by Race

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African-Americans, Hispanics have longer time from MM diagnosis to novel therapy initiation than whites
For myeloma patients with progressive disease (PD) after induction therapy

Salvage Therapy Does Not Up Survival for Progressive Myeloma

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Deepening of response through salvage therapy not linked to improved progression-free, overall survival
Autologous stem cell transplantation may be an effective treatment option in high-risk

ASCT May Offer Alternative for Tx of High-Risk Follicular Lymphoma

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Autologous stem cell transplantation explored for high-risk, early therapy failure FL prior to rituximab use
A two-dose course of recombinant zoster vaccine is associated with a reduction in the incidence of herpes zoster among adults who have undergone autologous hematopoietic stem cell transplantation

Two-Dose Course of Vaccine After HSCT Cuts Incidence of Zoster

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Incidence of herpes zoster decreased during median 21-month follow-up after autologous HSCT
Allogeneic hematopoietic cell transplantation with an unrelated donor results in better transplantation outcomes than cord blood transplantation in acute myeloid leukemia patients with active disease

Allo-HCT With Unrelated Donor Tied to Better Outcomes in AML

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In active AML, outcomes superior for allo-HCT with unrelated donor than for cord blood transplantation
A tool has been developed that can improve standardization and transparency when describing cell therapies

Experts Develop Standardized Tool for Describing Cell Therapies

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Consensus reached on contents of DOSES tool for improving standardization and transparency
For older patients undergoing allogeneic hematopoietic cell transplantation

Population Mortality Affects Long-Term Follow-Up of AlloHCT

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Substantial part of total nonrelapse mortality for older patients due to population mortality
A consensus statement for the use of hematopoietic stem cell transplantation in the treatment of multiple myeloma has been developed by Mayo Clinic physicians; the recommendations were published in the March issue of Bone Marrow Transplantation.

Recommendations Issued for HSCT in Multiple Myeloma

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Autologous stem cell transplant remains essential component of MM therapy in eligible patients
For children with B-cell precursor acute lymphoblastic leukemia with late bone marrow relapse

Favorable Outcomes Seen in Long Term for ALLR3 Trial

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Findings for risk-stratified tx in B-cell precursor acute lymphoblastic leukemia, late bone marrow relapse
In only the second known case worldwide

Second Man HIV-Free After Stem Cell Transplant

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Donor had double copy of gene mutation that confers natural resistance to HIV