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Initiation of statin therapy during childhood in patients with familial hypercholesterolemia slows the progression of carotid intima-media thickness and reduces the risk for cardiovascular disease over 20 years

Statins in Childhood Aid Familial Hypercholesteremia Outcomes

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Patients show slowed progression of carotid intima-media thickness, lower risk for cardiovascular disease
There is a dose-dependent relationship between diagnosis of osteoporosis and statin treatment

Statins Tied to Osteoporosis in Dose-Dependent Manner

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Low-dose statins may offer protective effect against osteoporosis
Lipophilic statin use is associated with significantly reduced hepatocellular carcinoma incidence and mortality in adults with chronic viral hepatitis

Lipophilic Statins May Cut Liver Cancer in Chronic Viral Hepatitis

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Inverse link is dose-dependent; lowest 10-year HCC risk seen with 600 or more lipophilic statin cDDDs
Among patients hospitalized for acute coronary syndrome

High-Intensity Lipid Lowering May Aid Very Elderly After ACS

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Benefit of simvastatin-ezetimibe combo after acute coronary syndrome greatest for patients ≥75 years
For elderly patients taking statins for primary prevention

Discontinuing Statins Linked to Cardiac Admissions in Elderly

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Admission risk for any cardiovascular event up with discontinuation among previously adherent seniors
There may be a dose-dependent relationship between statin therapy and new-onset diabetes across the duration of statin use

Statin Use Associated With Higher Incidence of Diabetes

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Findings show statin use tied to higher HbA1c values, with longer statin use tied to greater risk for diabetes
For cardiac patients with thorax and head or neck cancer

Statins May Be Beneficial After Radiation to Thorax, Head, Neck

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Statin use tied to reduction in stroke incidence for cardiac patients with thorax and head or neck cancer
The majority of young heart attack patients with familial hypercholesterolemia still have elevated cholesterol levels a year later

More Aggressive Statin Tx Needed After Heart Attack in Young Patients

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Majority of patients with heart attack <50 years still have high cholesterol one year later
Simvastatin's beneficial effects on clinical outcomes and brain atrophy in patients with multiple sclerosis are largely independent of cholesterol levels

Model Explores How Statins Alter Multiple Sclerosis Outcomes

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Loss of brain volume reduced in patients taking simvastatin independent of effect on cholesterol level
Use of statins before or after colorectal cancer diagnosis is linked to a lower risk for premature death

Statin Use With Colorectal Cancer Lowers Risk for Early Death

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Taking statins before or after cancer diagnosis cuts all-cause and cancer-related deaths