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The U.S. Preventive Services Task Force recommends that certain adults aged 40 to 75 years without cardiovascular disease history but with one or more cardiovascular risk factors initiate statins. These recommendations are included in the final recommendation statement published in the Nov. 15 issue of the Journal of the American Medical Association

USPSTF Advises Statins for Some Adults With No CVD History

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Recommendation for those aged 40 to 75 years with one or more risk factor, 10-year risk of ≥10 percent
The odds of surviving cardiac arrest seem higher for patients who've been taking statins

AHA: Survival Odds Up With Statins Before Cardiac Arrest

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Those already taking statin medication more likely to be alive one year later
There is a graded association between intensity of statin therapy and mortality for patients with established atherosclerotic cardiovascular disease

High-Intensity Statins Tied to Better Survival in CVD Patients

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Significant survival advantage compared with moderate-intensity statins, even among older adults
For patients without diabetes

Incidence of Statin-Associated T2DM Relatively Low

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Diabetogenic impact of statins increases as fasting plasma glucose, triglycerides, and BMI increase
For patients with type 2 diabetes mellitus

Statins Offset Insulin-Related Cancer Risk in T2DM

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Risks of cancer reduced with statins; greater risk reduction in those not receiving antihyperglycemic tx
Statins can interact with other drugs prescribed for cardiovascular disease

AHA Urges Awareness of Statin Interaction With Other CV Meds

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Lovastatin, simvastatin, pravastatin should not be used with gemfibrozil
Statin therapy is associated with reduced risk of all-cause and multiple myeloma-specific mortality

Statins Reduce Risk of Mortality in Multiple Myeloma

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Reduced risk of both all-cause and multiple myeloma-specific mortality in cohort of veterans
Treatments other than statins also can effectively reduce cardiovascular risk

Both Statin, Non-Statin Therapies Effective for Lowering LDL

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Dietary changes, other meds, and even surgery can lower cardiovascular risk similarly to statins
European and American guidelines lead to different recommendations for statin therapy

European, American Guidelines Lead to Different Recs for Statins

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Quantification of CAC score can improve stratification for those at high, low risk for events
Nearly all middle-aged patients with diabetes should be taking statins

Too Few Diabetes Patients Receiving Statins

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Two in five middle-aged patients don't get the medications, despite recommendations to do so