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Adherent patients receiving high-intensity statin and/or ezetimibe therapy have the lowest cardiovascular risk

Adherence and Intensity of Lipid-Lowering Tx Influence CV Risk

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Lowest risk seen for adherent patients receiving high-intensity statin and/or ezetimibe regimen
Statins are associated with a low risk for side effects

AHA Scientific Statement: Low Risk of Side Effects for Statins

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Risk for statin-induced serious muscle injury <0.1 percent, newly diagnosed diabetes ~0.2 percent
The onset of musculoskeletal adverse events during statin monotherapy is significantly faster with use of atorvastatin and rosuvastatin versus simvastatin

Onset of Musculoskeletal Adverse Events Varies Between Statins

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Significantly faster onset with atorvastatin, rosuvastatin versus simvastatin during monotherapy
First-year nonadherence and discontinuation are high among older adults prescribed statins

Nonadherence, Discontinuation of Statins High in 1st Year of Rx

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Among older adults prescribed statins, diabetes, anxiety linked to nonadherence, discontinuation
There is a lack of convincing evidence for an association between statin use and non-cardiovascular disease outcomes

Link Between Statins, Non-CVD Outcomes Lacks Evidence

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Review of observational studies, randomized trials shows absence of convincing evidence
Preoperative statin therapy is associated with higher long-term survival following abdominal aortic aneurysm repair

Statins Improve Long-Term Survival After AAA Repair

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Findings in those taking statins before abdominal aortic aneurysm repair or initiating before discharge
Statin use is not associated with reduced risk of atherosclerotic cardiovascular disease or all-cause mortality among older adults without type 2 diabetes

Widespread Statin Use Not Recommended in Old, Very Old

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No benefit in healthy elderly patients; protective effect limited to those with type 2 DM aged 75 to 84
Guideline-concordant statin prescribing rates are increased modestly with use of an automated dashboard using active choice framing and peer comparison

PCP Statin Prescribing Up With Automated Patient Dashboard

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Modest increase in prescribing with automated dashboard using active choice framing for PCPs
African-Americans are less likely than whites to be treated with statins or to receive a statin at guideline-recommended intensity

African-Americans Less Likely to Get Recommended Statin Therapy

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Socioeconomic, demographic, belief-related and clinician differences are contributing factors
Women are less likely than men to fill a prescription for high-intensity statins after hospitalization for myocardial infarction

Women Less Likely to Fill Post-MI Statin Prescription

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56 percent of men, 47 percent of women filled high-intensity statin after myocardial infarction