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A lawsuit over the antipsychotic drug Risperdal has led to an $8 billion punitive damages award against Johnson & Johnson and one if its subsidiaries.

$8 Billion Award Granted in Risperdal Lawsuit

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Plaintiff's attorneys say drug is linked to abnormal growth of female breast tissue in boys
Heart disease is associated with an increased risk for hospital admission for allopurinol-associated severe cutaneous adverse reactions

Heart Disease May Up Risk for Allopurinol-Linked Cutaneous AEs

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Risk for hospital admission increased for allopurinol-associated severe cutaneous adverse reactions
The risk for aortic and mitral regurgitation is increased with current and recent fluoroquinolone use

Aortic, Mitral Regurgitation Risk Up With Fluoroquinolone Use

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Risk significantly increased for current use and recent use, but not past use within 61 to 365 days
Aspirin for primary prevention of cardiovascular disease is likely to result in net benefit for some patients

Aspirin for Primary Prevention May Offer Net Benefit for Some

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Subgroups with net benefit had higher baseline CVD risk, higher levels of most established CVD risk factors
Use of the widely prescribed opioid tramadol is associated with a greater risk for developing hypoglycemia compared with almost every other opioid

Use of Pain Reliever Tramadol May Up Risk for Hypoglycemia

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Retrospective analysis of adverse events reported to FDA shows risk similar to that seen with methadone
Initiation of therapy with sodium-glucose cotransporter-2 inhibitors for type 2 diabetes mellitus is not associated with an increased risk for urinary tract infection events compared with initiation of other second-line antidiabetic medications

SGLT-2 Inhibitor Use Not Linked to Increased Risk for UTI Events

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Findings seen in propensity-matched cohorts versus receipt of DPP-4 inhibitors or GLP-1 agonists
For patients with relapsed multiple myeloma

Cardiovascular AEs Common With Carfilzomib in Multiple Myeloma

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Patients with relapsed multiple myeloma experiencing CVAEs had inferior survival
Cardiac radiation dose exposure is a modifiable cardiac risk factor for major adverse cardiac events and all-cause mortality in patients with non-small cell lung cancer

Cardiac Radiation Dose in NSCLC Predicts Mortality, Cardiac AEs

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In coronary heart disease-negative patients, mean heart dose associated with all-cause mortality
Gabapentinoids are associated with increased risks for adverse outcomes related to coordination disturbances

Gabapentinoids Linked to Increased Risk for Significant Adverse Outcomes

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Risk increased for suicidal behavior, unintentional overdose, road traffic incident, head/body injuries
Consumption of dietary supplements

Dietary Supplements May Up Risk for Severe Medical Events

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Increased risk seen in association with supplements sold for muscle building, energy, weight loss