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Tag: Sickle-Cell Anemia

For patients with severe hemoglobinopathies undergoing bone marrow transplantation

Increasing Dose for Total Body Irradiation Cuts Graft Failure

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Findings seen in patients with severe hemoglobinopathies receiving haploidentical bone marrow transplantation
A sickle cell disease prevention and treatment program in the United States has been reauthorized to receive nearly $5 million each year over the next five years.

New Law Boosts Fight Against Sickle Cell Disease

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In 2018, the National Institutes of Health was funded approximately $115 million for research of the disease
For patients with sickle cell-related pain

L-Glutamine Reduces Number of Pain Crises in Sickle Cell Disease

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Significantly fewer pain crises, hospitalizations compared with those receiving placebo
For African-Americans

Sickle Cell Trait Not Linked to Stroke in African-Americans

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Meta-analysis of four cohorts shows sickle cell trait not linked to incidence of ischemic stroke
In patients with sickle cell anemia

Ceruloplasmin ID’d As Marker of Kidney Disease in Sickle Cell

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Findings part of proteomic analysis of urine in patients with sickle cell disease
Adherence to antibiotic guidelines for acute chest syndrome in children with sickle cell disease varies widely

Antibiotic Rx Adherence Varies Widely in Sickle Cell Care

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Guideline-adherent therapy tied to fewer 30-day readmissions
The U.S. Food and Drug Administration has approved Endari (L-glutamine oral powder) to treat patients with sickle cell disease.

FDA Approves Endari for the Treatment of Sickle Cell Disease

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First treatment approved for patients with sickle cell disease in almost 20 years
In a brief report published in the March 2 issue of the New England Journal of Medicine

Gene Therapy Described in a Patient With Sickle Cell Disease

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But treatment has only been given to one patient so far
Hemoglobin A1c measurements may be less accurate in black people who have sickle cell trait

Sickle Cell Trait May Affect Reliability of HbA1c Readings

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HbA1c levels significantly lower than in people without sickle cell trait
High-dose crizanlizumab treatment is associated with a significantly lower rate of sickle cell-related pain crises than placebo

ASH: Lower Rate of Sickle Cell Pain Crises With Crizanlizumab

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Lower rate of crises per year; longer median time to first, second crises with high-dose therapy