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Tag: Sickle-Cell Anemia

In patients with sickle cell anemia

Ceruloplasmin ID’d As Marker of Kidney Disease in Sickle Cell

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Findings part of proteomic analysis of urine in patients with sickle cell disease
Adherence to antibiotic guidelines for acute chest syndrome in children with sickle cell disease varies widely

Antibiotic Rx Adherence Varies Widely in Sickle Cell Care

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Guideline-adherent therapy tied to fewer 30-day readmissions
The U.S. Food and Drug Administration has approved Endari (L-glutamine oral powder) to treat patients with sickle cell disease.

FDA Approves Endari for the Treatment of Sickle Cell Disease

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First treatment approved for patients with sickle cell disease in almost 20 years
In a brief report published in the March 2 issue of the New England Journal of Medicine

Gene Therapy Described in a Patient With Sickle Cell Disease

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But treatment has only been given to one patient so far
Hemoglobin A1c measurements may be less accurate in black people who have sickle cell trait

Sickle Cell Trait May Affect Reliability of HbA1c Readings

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HbA1c levels significantly lower than in people without sickle cell trait
High-dose crizanlizumab treatment is associated with a significantly lower rate of sickle cell-related pain crises than placebo

ASH: Lower Rate of Sickle Cell Pain Crises With Crizanlizumab

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Lower rate of crises per year; longer median time to first, second crises with high-dose therapy
Sickle cell trait is not associated with a higher risk of death than absence of the trait

Sickle Cell Trait Doesn’t Up Mortality Risk in U.S. Soldiers

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However, SC trait was linked with significantly higher risk of exertional rhabdomyolysis
Hydroxyurea may help preserve lung function in children with sickle cell disease

ATS: Hydroxyurea Can Up Lung Function in Sickle Cell Disease

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Drug slowed down the annual decline children had been showing before starting treatment
The rate of vaso-occlusive crisis events is not significantly lower for children and adolescents with sickle-cell anemia receiving prasugrel versus placebo

ASH: Prasugrel Doesn’t Cut Vaso-Occlusive Crisis in Sickle Cell

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Rate of vaso-occlusive crisis events is not lower for children receiving prasugrel versus placebo
Less than one-quarter of sickle cell anemia patients who should have been taking hydroxyurea within a year of their last pain crisis actually were taking the medication

Hydroxyurea Underutilized for Patients With Sickle Cell

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Only 23 percent using the drug within a year of their last pain crisis