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Tag: Sickle-Cell Anemia

Broader Genetic Testing Could ID More Heritable Cancers

ASH: CRISPR-Cas9 Gene Editing Promising in TDT, SCD

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Total hemoglobin, fetal Hb increased in five patients with transfusion-dependent ß-thalassemia, two with sickle cell disease

Use of medical marijuana is associated with fewer hospitalizations among patients with sickle cell disease

Medical Marijuana Tied to Fewer Admissions in Sickle Cell Disease

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But no change in opioid use observed for those receiving medical marijuana certification
Endurance exercise training may improve skeletal muscle microvasculature in patients with sickle cell disease

Endurance Exercise May Offer Vascular Benefit in Sickle Cell Disease

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Increases in capillary density, functional exchange surface seen in microvasculature of skeletal muscle
A U.S. clinical trial of CRISPR gene-editing to treat people with sickle cell disease is underway.

Trial Tests CRISPR Gene-Editing to Treat Sickle Cell Disease

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Study seeks to recruit up to 45 adults with severe sickle cell disease
For individuals with sickle cell disease

Voxelotor Improves Hemoglobin Levels in Sickle Cell Disease

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Fewer individuals in voxelotor group versus placebo group have worsened anemia at week 24
For patients with severe hemoglobinopathies undergoing bone marrow transplantation

Increasing Dose for Total Body Irradiation Cuts Graft Failure

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Findings seen in patients with severe hemoglobinopathies receiving haploidentical bone marrow transplantation
A sickle cell disease prevention and treatment program in the United States has been reauthorized to receive nearly $5 million each year over the next five years.

New Law Boosts Fight Against Sickle Cell Disease

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In 2018, the National Institutes of Health was funded approximately $115 million for research of the disease
For patients with sickle cell-related pain

L-Glutamine Reduces Number of Pain Crises in Sickle Cell Disease

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Significantly fewer pain crises, hospitalizations compared with those receiving placebo
For African-Americans

Sickle Cell Trait Not Linked to Stroke in African-Americans

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Meta-analysis of four cohorts shows sickle cell trait not linked to incidence of ischemic stroke
In patients with sickle cell anemia

Ceruloplasmin ID’d As Marker of Kidney Disease in Sickle Cell

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Findings part of proteomic analysis of urine in patients with sickle cell disease