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Tag: Seizures

For patients with drop seizures associated with Lennox-Gastaut syndrome

Cannabidiol Efficacious for Lennox-Gastaut Drop Seizures

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Cannabidiol is associated with a greater reduction in monthly drop seizure frequency versus placebo
From 2002 to 2015 there was a substantial increase in gabapentinoid use

Increase Seen in Gabapentinoid Use From 2002 to 2015

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More than three-fold increase in percentage of adults using gabapentin and/or pregabalin
Non-pharmaceutical therapies may offer seizure relief for children with epilepsy

Non-Drug Options Provide Seizure Relief in Children

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And, slow initiation of the ketogenic diet shows good outcomes in children with epilepsy
The relative risk of a seizure disorder after eclampsia is higher than that of women unaffected by eclampsia but remains extremely low

Eclampsia Tied to Increased Relative Risk of Seizure Disorder

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However, the risk remains extremely low, at 4.58/10,000 person-years
For pediatric patients with drug-resistant epilepsy

Surgery Reduces Seizures in Drug-Resistant Epilepsy

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And most common diagnoses based on resected brain specimens include hippocampal sclerosis, tumors
For critically ill patients

2HELPS2B Model Identifies Seizure Risk in Critically Ill

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Area under curve of 0.819, average calibration error of 2.7 percent for model comprising six variables
De novo KCNB1 missense and loss-of-function variants are associated with neurodevelopmental disorders

Phenotype Varies for Presumed Pathogenic Variants in KCNB1

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De novo mutations in KCNB1 associated with variable neurodevelopmental disorder

Review: Levetiracetam Best Monotherapy for Partial Seizures

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First-line tx sodium valproate tops carbamazepine, topiramate for generalized onset seizures
Undetected seizures may contribute to some symptoms associated with Alzheimer's disease

Silent Seizures May Contribute to Alzheimer’s Pathology

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Early occult hippocampal hyperexcitability may contribute to pathogenesis of AD, researchers say
Many infants with infantile spasms aren't promptly diagnosed

Diagnosis of Infantile Spasms Too Often Delayed

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Parents, doctors may not recognize infantile spasms early enough to prevent brain damage