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The injected drug Siliq (brodalumab) has been approved by the U.S. Food and Drug Administration to treat moderate-to-severe plaque psoriasis in adults.

FDA Approves Siliq for Plaque Psoriasis

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Injected medication approved for use by patients who've failed other treatments
About half of patients with chronic plaque psoriasis have fatigue

Fatigue Occurs in ~50 Percent With Chronic Plaque Psoriasis

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Objective measures of psoriasis disease activity are not associated with fatigue severity
Childhood psoriasis impacts parents' quality of life in multiple domains

Psoriasis Impacts QoL for Parents of Affected Children

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Negative impact on quality of life in multiple domains, especially emotional well-being
Patients with psoriasis report wanting to be treated as individuals and preferring individualized health education

Consultations Rarely Address Psoriasis Patients’ Concerns

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Patients report wanting to be met as individuals, prefer individualized health education
Obese patients with psoriasis who lose 10 to 15 percent of their weight may see significant and lasting improvement in their symptoms

Reduction in Psoriasis Symptoms With Long-Term Weight Loss

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Quality-of-life boost seen in obese patients who lost significant amounts of weight
Patients with psoriatic arthritis have higher levels of fatigue than patients with psoriasis treated with phototherapy or systemic treatment

Fatigue Levels Vary for Patients With Psoriatic Disease

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Higher levels of fatigue in psoriatic arthritis versus psoriasis; fatigue scores linked to depression
Gastric bypass

Gastric Bypass Associated With Reduced Risk of Psoriasis

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Reduced risks of psoriasis, severe psoriasis, psoriatic arthritis with bypass, but not banding
Prenatal exposure to maternal bereavement is associated with psoriasis only for children born to a mother who lost a partner/spouse or an older child

Prenatal Exposure to Maternal Stress May Raise Psoriasis Risk

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But link to psoriasis seen only for children born to mothers who lost a partner/spouse or an older child
For patients with psoriasis

Rapid, Clinically Meaningful Psoriasis Relief With Ixekizumab

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Three clinical trials show significant improvements for ixekizumab versus etanercept, placebo
Psoriasis patients have increased global arterial inflammation and subcutaneous inflammation

Increased Global, Subcutaneous Inflammation in Psoriasis

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Increased 18F-fluorodeoxyglucose uptake values indicate arterial and subcutaneous inflammation