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The extracutaneous manifestations of psoriasis and guidance on use of biologic treatment for management of psoriasis are discussed in two new guidelines published online Feb. 13 in the Journal of the American Academy of Dermatology.

Guideline Covers Extracutaneous Manifestations of Psoriasis

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Second guideline presents evidence for different biologic agents, including adverse events
Treatment of psoriasis with biologic therapy is associated with a reduction in noncalcified coronary plaque and improved plaque morphology

Psoriasis Tx Linked to Drop in Noncalcified Coronary Plaque

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Noncalcified plaque burden and necrotic core reduced in association with biologic therapy
Methotrexate is well tolerated and effective for psoriasis in a Chinese population and is more effective for those without psoriatic arthritis

Methotrexate Well Tolerated, Effective for Psoriasis in Chinese

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Greater therapeutic response, fewer adverse events seen in those without psoriatic arthritis
Psoriasis is associated with an increased risk for cardiovascular interventions in patients with hypertension

Hypertension With Psoriasis Tied to More Cardiac Interventions

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In patients with hypertension, psoriasis linked to increased risk for cardiovascular procedures, surgeries
Depending on the definition used

Classification of Psoriasis Severity Depends on Definition

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Authors call for international standardization defining moderate-to-severe psoriasis
Recommendations have been developed for pharmacologic and nonpharmacologic treatment of psoriatic arthritis; the evidence-based guideline was published online Nov. 30 in Arthritis & Rheumatology.

Recommendations Developed for Psoriatic Arthritis Treatment

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Guideline includes use of treat-to-target strategy for all adult patients with active PsA
Cardiovascular risk should be carefully evaluated in patients with psoriatic arthritis

Higher Cardiovascular Risk Seen With Psoriatic Arthritis

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Risk seems to be increased especially in patients with a high inflammatory burden, late-onset psoriasis
A new scoring system that accounts for "not relevant" responses on the Dermatology Life Quality Index for patients with psoriasis is valid for avoiding bias and can improve access to biologics

Novel Scoring System Can Up Access to Biologics in Psoriasis

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DLQI-R allows more patients to achieve threshold for becoming candidates for biologic treatment
Psoriasis appears to be significantly associated with inflammatory bowel disease

Psoriasis Linked to Increased Risk for Inflammatory Bowel Disease

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Significant associations observed between psoriasis and risk for Crohn's disease, ulcerative colitis
Halobetasol propionate 0.01 percent lotion (BRYHALI Lotion) appears safe and effective for the treatment of moderate-to-severe plaque psoriasis

Halobetasol Propionate Lotion Shows Efficacy for Tx of Psoriasis

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Findings based on two phase 3 trials of halobetasol propionate lotion versus vehicle