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Proton pump inhibitors may increase risk of premature mortality when taken for extended periods

Proton Pump Inhibitors Linked to Higher Mortality Risk

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Researchers find association between prolonged use of certain meds and increased risk of early death
Proton pump inhibitors don't appear to increase the risk of dementia

PPIs Not Found to Raise Risk of Alzheimer’s Disease

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New research debunks other studies suggesting that PPIs cause mental decline
For patients with dementia

Proton Pump Inhibitor Use Ups Pneumonia Risk in Dementia

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Independent risk factors for pneumonia include age, male gender, underlying cerebrovascular disease
Use of gastric acid suppressants may increase the risk of recurrent Clostridium difficile infection

Gastric Acid Suppressants May Up Risk of Recurrent C. difficile

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Meta-analysis shows increased risk of recurrent CDI, even after adjustment for age and confounders
For patients with Barrett's esophagus

No Chemopreventive Effect Seen for H2RAs in Barrett’s Esophagus

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PPI use, but not H2 receptor antagonists, linked to reduced risk of progression in Barrett's esophagus
Women who take acid-suppressing medications during pregnancy may have a child at increased risk of developing asthma

Acid Suppression in Pregnancy Linked to Childhood Asthma

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Review suggests, but doesn't prove, offspring one-third more likely to see a doctor for asthma
Proton pump inhibitor and H2 receptor antagonist users may be at higher risk of infection with Clostridium difficile and Campylobacter bacteria

Acid Suppression Rx Linked to Risk of C. difficile, Campylobacter

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Study suggests long-term use might open door to C. difficile and Campylobacter bacteria
For patients beginning warfarin therapy

PPI Cuts Risk of Warfarin-Related Upper GI Bleeding

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Greatest reduction in risk seen for patients also taking antiplatelet drugs or NSAIDs
Thirty-seven percent of premature infants receive gastroesophageal reflux medications

Preemies Often Receive Gastroesophageal Reflux Meds

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Seventy-seven percent of those on medications started after NICU discharge; prolonged use common
Long-term proton pump inhibitor use is associated with increased risk of fundic gland polyps

Review Links PPI Use With Risk of Fundic Gland Polyps

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Proton pump inhibitor therapy may also be associated with increased risk of gastric cancer