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Tag: Proton Pump Inhibitors

Recommendations are presented for the management of eosinophilic esophagitis in clinical practice guidelines published in the May issue of Gastroenterology.

Guidelines Issued for Managing Eosinophilic Esophagitis

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Topical glucocorticosteroids recommended over no treatment
Stomach acid suppression medications increase the odds of intestinal colonization with multidrug-resistant microorganisms

Suppressing Stomach Acid May Up Intestinal Growth of MDROs

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Gastric acid suppression increased odds of intestinal colonization with MDROs by about 75 percent
Proton pump inhibitors taken for acid reflux may lead to an increased risk for fractures in children and adolescents

Proton Pump Inhibitor Therapy May Up Fracture Risk in Children

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Fracture risk remained higher after adjusting for differences in sex, race, other factors
Proton pump inhibitor use in children is associated with a small but significant increased risk for any fracture

Proton Pump Inhibitors May Up Fracture Risk in Children

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Small but significant risk seen for upper-limb and lower-limb fractures
Use of acid reflux drugs (proton pump inhibitors) during and after cancer treatment may be tied to impaired memory and concentration in breast cancer survivors

Use of PPIs Tied to Cognitive Issues in Breast Cancer Survivors

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Concentration, memory problems reported in breast cancer patients at different stages of survivorship
Gastroesophageal reflux disorder symptoms are common

Half of Patients on PPIs for GERD Still Have Persistent Symptoms

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Heartburn, regurgitation reported by 54.1 percent of participants taking proton pump inhibitor daily
Continuous use of proton pump inhibitor therapy is associated with an increased risk for acute gastroenteritis during winter epidemic periods with peak circulation of enteric viruses

Continuous PPI Use May Increase Risk for Acute Gastroenteritis

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Risk for acute gastroenteritis icreased for all ages combined and for those aged 45 to 64, 65 to 74, ≥75
Infants who are given acid suppression therapy in their first year of life are more likely to subsequently break a bone

Antacid Use in First Year of Life Tied to Later Fracture Risk

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Findings seen among healthy infants taking proton pump inhibitors alone or with histamine H2-receptor antagonists
Use of pantoprazole for up to three years to prevent upper gastrointestinal events in patients receiving anticoagulant therapy with aspirin and/or rivaroxaban has a similar safety profile to placebo except for an increased risk for enteric infections

PPI Use for Up to Three Years Safe During Anticoagulant Tx

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Safety profile did not differ for pantoprazole versus placebo except greater risk for enteric infections
Taking proton pump inhibitors is associated with an excess of cause-specific mortality

Excess Cause-Specific Mortality Tied to Chronic Proton Pump Inhibitor Use

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Excess mortality due to CVD, CKD, upper GI cancer for those with no indication for PPI use