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Tag: Proton Pump Inhibitors

Pantoprazole Cuts GI Bleeding in Patients Undergoing Invasive Ventilation

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Pantoprazole yields lower clinically important upper GI bleeding, with no significant change in mortality versus placebo

Use of Acid-Suppression Therapy Linked to Migraine, Severe Headache

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Adjusted odds ratios of 1.70, 1.40, and 1.30 seen for proton pump inhibitors, H2 receptor antagonists, and generic antacids, respectively

Cumulative PPI Use for More Than 4.4 Years Linked to Increased Risk for Dementia

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No significant association seen for lesser durations of proton pump inhibitor use

ASN: PPI Use May Up Risk for AKI After Cardiac Surgery

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Adults receiving proton pump inhibitors have increased risk for acute kidney injury requiring dialysis following cardiac surgery

Proton Pump Inhibitor Use Tied to Less Severe Periodontal Disease

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Patients with periodontitis who use proton pump inhibitors have fewer teeth with elevated probing depths for the gap between teeth and gums

Add-On PPI Therapy May Improve Glycemic Control in Diabetes

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However, treatment with proton pump inhibitors is not associated with risk for incident diabetes in the general population

Child Proton Pump Inhibitor Use May Increase Asthma Risk

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Risk increased across all age groups with highest risk for infants and toddlers; risk seen across individual PPIs

Regular use of proton pump inhibitors is associated with an increased risk for type 2 diabetes

Proton Pump Inhibitor Use Linked to Increased T2DM Risk

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Type 2 diabetes risk increased with increasing length of PPI use, particularly use for more than two years
For patients with advanced urothelial cancer treated with atezolizumab

PPI Use Is Negative Prognostic Marker in Urothelial Cancer

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PPI use linked to significantly worse progression-free, overall survival in advanced urothelial cancer
Adults taking proton pump inhibitors have an increased risk for having a positive COVID-19 test

Risk for COVID-19 Increased for Adults Taking PPIs

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Dose-response relationship observed; risk up 3.67-fold for those using PPIs up to twice daily