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Deferiprone Not Beneficial for Newly Diagnosed Parkinson Disease

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Greater decrease seen in nigrostriatal iron content with deferiprone, but more patients have symptom progression leading to initiation of dopaminergic therapy

Buprenorphine Use in Pregnancy May Reduce Risk for Adverse Neonatal Outcomes

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Risk for preterm birth, small size for gestational age, low birth weight lower for those receiving buprenorphine versus methadone

Lecanemab Reduced Markers of Amyloid in Early Alzheimer Disease

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Moderately less decline seen in cognition and function at 18 months with lecanemab versus placebo

Use of New-to-Market Neurologic Medications Reported to Be Low

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Use of most new-to-market meds was <20 percent; costs for these medications were substantially larger

Convection-Enhanced Delivery of Topotecan Active in Glioblastoma

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Catheter pump system capable of CED of topotecan well tolerated and active in recurrent glioblastoma

Benzodiazepine Exposure in Pregnancy Does Not Up Risk for ADHD, Autism

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No significantly increased risk seen for ADHD or ASD with exposure to benzodiazepines during first, second, third trimester

Extended-Release Morphine Does Not Reduce Breathlessness in COPD

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One week of extended-release morphine does not significantly reduce the intensity of worst breathlessness

Second Death in Trial of Experimental Alzheimer Drug Raising Concerns

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Doctors suspect that by stripping away amyloid deposits, lecanemab weakens blood vessels and leaves them vulnerable to bleeds

Risk of Uterine Diseases, Cancers Up With Tamoxifen Treatment

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After adjustment for confounding variables, risk of endometrial cancer was increased almost fourfold with tamoxifen treatment

Combination Treatment Beneficial in Albuminuric CKD

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7.4 year gain in event-free survival for 50-year-old patients with combo therapy with ACEi/ARB and SGLT2 inhibitors