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Solanezumab Does Not Slow Cognitive Decline in Preclinical Alzheimer Disease

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Mean change in Preclinical Alzheimer Cognitive Composite score not significantly different at 240 weeks with solanezumab, placebo

One-Hour Training Improves Documentation to Diagnose, Treat Tardive Dyskinesia

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Implementation of training session increased proportion of patients with documented Abnormal Involuntary Movement Score

Donanemab Slows Clinical Progression in Early Alzheimer Disease

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Slows clinical progression at 76 weeks for those with low/medium tau and the combined low/medium and high tau pathology population

Determinants of Overall Survival in Metastatic Uveal Melanoma Identified

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Female sex, anti-CTLA‐4 therapy, and anti-PD‐1 therapy linked to better overall survival, while worse survival seen with hepatic metastases

Treatment Effect of Tofacitinib, Adalimumab Compared in RA

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Modest reduction seen in DAS28-CPR at three months for those receiving TOF versus ADA, but no difference seen at nine months

Pharmacy-Level Stewardship Can Save on Immune Checkpoint Inhibitors

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Strategies include dose rounding and vial sharing, as well as weight-based dosing

European Regulators Investigating Risk for Suicidal Thoughts With Popular Weight-Loss Drugs

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Three case reports from Iceland spurred the review; two of the cases involved Ozempic

Stimulant Treatment for Childhood ADHD Not Linked to Substance Use

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No evidence seen for link between childhood stimulant treatment and substance use during adolescence and young adulthood

Variation Seen in Dosing of Meds at Prehospital Pediatric Encounters

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Lowest consistency with guidelines was seen for diazepam and lorazepam; most deviations represented an underdose

P2Y₁₂ Inhibitor Monotherapy Better Than Aspirin in Coronary Artery Disease

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Reduced risk seen for composite of cardiovascular death, myocardial infarction, and stroke