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Orexin Receptor 2 Agonist Improves Sleepiness in Narcolepsy

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Improvement seen in measures of sleepiness, cataplexy over eight weeks versus placebo, but drug was associated with hepatotoxic effects

2001 to 2020 Saw Shift in Rx for Disease-Modifying Therapy for Multiple Sclerosis

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Oral disease-modifying therapies dominated new initiations by 2020 to 62.3 percent

Voclosporin Safe, Effective for Long-Term Treatment of Lupus Nephritis

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Benefits include maintenance of urine protein creatinine ratio reductions, preserved kidney function

Maternal Labor Epidural Analgesia May Be Linked to Autism in Children

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Risk increased with labor epidural analgesia alone and labor epidural analgesia and oxytocin compared with no exposure

Younger Kidney Cancer Patients on VEGF Inhibitors at Elevated Risk for Hypertension

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Vascular endothelial growth factor inhibitors tied to hypertension among people aged 18 to 39 years being treated for renal cancer

Major Drug Shortages Not Likely After Tornado Damages Pfizer Plant, FDA Says

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Pfizer is working to repair the damage and mitigate any shortage of drugs made at the facility

SGLT2i Use Linked to Reduced Risk for Flare in Adults With Gout, T2D

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Flare rate lower among SGLT2i initiators than DDP-4i initiators; gout-primary emergency department visits, hospitalizations also reduced

Ketamine Efficacious for Treatment-Resistant Depression

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Four-week course efficacious and safe for treatment-resistant depression

Fruquintinib Provides Meaningful Benefit in Refractory Metastatic CRC

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Significantly improved overall survival seen with fruiquintinib versus placebo, with favorable safety profile

JAK Inhibitors May Aid Hair Regrowth in Patients With Alopecia

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Study shows safety and tolerability of JAK inhibitors acceptable