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Nirmatrelvir/Ritonavir Cuts COVID-19 Complications in Highest-Risk Patients

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Risk for COVID-19 hospitalization or death reduced for those who were severely or moderately immunocompromised

Durable Reductions in HbA1c, Body Weight Seen With Semaglutide

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Real-world study shows greater reductions in HbA1c and body weight for patients with proportion of days covered ≥60 percent

Major Drug Companies Agree to Price Negotiations With U.S. Government

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Ten drugs have been chosen for price negotiations by the Centers for Medicare & Medicaid Services

Extended-Release Buprenorphine Not Necessarily Cost-Effective

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Extended-release buprenorphine not cost-effective when transmucosal buprenorphine is available for treatment of OUD

Cediranib Shows Promise for Differentiated Thyroid Cancer

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No significant improvement in progression-free, overall survival seen with addition of lenalidomide to cediranib

Cases of Pediatric Therapeutic Errors Related to ADHD Meds on the Rise

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Likelihood of experiencing a serious medical outcome or being admitted to a health care facility was increased for children younger than 6 years

Lorundrostat Effective for Lowering BP in Uncontrolled Hypertension

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Changes in office systolic BP of −14.1, −13.2, −6.9, and −4.1 mm Hg seen with 100, 50, 12.5 mg once daily of lorundrostat and placebo

Use of Nonselective β-Blockers Tied to Lower Risk for Total Knee Arthroplasty

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Any β-blocker use cuts odds by nearly half, driven by nonselective β1-blockers

E-Cigarettes, Cytisine, Varenicline Most Effective to Help Stop Smoking

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Combination of a patch and fast-acting nicotine replacement therapy also effective

Hypertension, Statin Use Increased for Individuals Using TAF for PrEP

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Incident hypertension, statin use higher with tenofovir alafenamide fumarate compared with tenofovir disoproxil fumarate