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Two newly approved medications to treat high cholesterol are extremely overpriced compared to the health benefits they give to patients

ICER: New Cholesterol Drugs Highly Overpriced

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Newly FDA-approved Repatha and Praluent currently cost more than $14,000 per year
Imetelstat

Imetelstat Deemed Active in Myelofibrosis, Thrombocythemia

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Responses for patients with myelofibrosis, essential thrombocythemia
None of 657 patients who took a daily pill to prevent HIV infection contracted the virus over a period of more than two years

Daily PrEP Prevents HIV Infection in High-Risk Individuals

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Study participants were infected with other sexually transmitted diseases
For patients with diabetic nephropathy receiving an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker

Finerenone Linked to Improved UACR in Diabetic Nephropathy

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Addition of finerenone to ACE inhibitor or ARB tied to reduction in urinary albumin-creatinine ratio
For patients with rheumatoid arthritis with prior biologic exposure

Study Compares Hospitalized Infection Risk for Biologics in RA

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Risk of hospitalized infection increased with etanercept, infliximab, rituximab versus abatacept
For patients with established Chagas' cardiomyopathy

Benznidazole Tx Explored in Chagas’ Cardiomyopathy

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Reduces serum parasite detection but does not reduce cardiac clinical deterioration through 5 years
For patients with an acute coronary syndrome undergoing percutaneous coronary intervention

Bivalirudin Doesn’t Lower Major Cardiovascular Event Rate in ACS

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No decrease in rate of major CV events, net adverse clinical events for patients undergoing PCI
The risk of osteonecrosis of the jaw is highest in association with intravenous bisphosphonate use

Osteonecrosis of Jaw Risk Highest for IV Bisphosphonate Use

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High risk for zoledronate, denosumab mainly in prevention of skeletal-related events
Intravenous cyclosporine does not improve outcomes versus placebo in patients with anterior ST-segment elevation myocardial infarction who had been referred for primary percutaneous coronary intervention. The findings were published online Aug. 30 in the New England Journal of Medicine to coincide with the annual European Society of Cardiology Congress

Intravenous Cyclosporine Doesn’t Improve STEMI Outcomes

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For patients undergoing PCI, cyclosporine doesn't prevent adverse left ventricular remodeling at 1 year
For patients taking dabigatran

Lower Risk of Dabigatran-Tied Bleeding With Gastroprotection

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Concomitant use of gastroprotective agents linked to lower risk of gastrointestinal bleeding