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The risk of osteonecrosis of the jaw is highest in association with intravenous bisphosphonate use

Osteonecrosis of Jaw Risk Highest for IV Bisphosphonate Use

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High risk for zoledronate, denosumab mainly in prevention of skeletal-related events
Intravenous cyclosporine does not improve outcomes versus placebo in patients with anterior ST-segment elevation myocardial infarction who had been referred for primary percutaneous coronary intervention. The findings were published online Aug. 30 in the New England Journal of Medicine to coincide with the annual European Society of Cardiology Congress

Intravenous Cyclosporine Doesn’t Improve STEMI Outcomes

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For patients undergoing PCI, cyclosporine doesn't prevent adverse left ventricular remodeling at 1 year
For patients taking dabigatran

Lower Risk of Dabigatran-Tied Bleeding With Gastroprotection

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Concomitant use of gastroprotective agents linked to lower risk of gastrointestinal bleeding
For patients with type 2 diabetes

Patient Satisfaction Up for Dulaglutide Treatment in T2DM

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Improvement in patient satisfaction, decrease in perceived frequency of hyperglycemia
Daratumumab monotherapy has a favorable safety profile and encouraging efficacy in patients with heavily pretreated and refractory myeloma in a phase 1-2 trial. The results of the study were published online Aug. 26 in the New England Journal of Medicine.

Daratumumab Monotherapy Promising for Multiple Myeloma

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Findings in a phase 1-2 study of patients with relapsed myeloma or relapsed/refractory myeloma
For most atrial fibrillation patients taking warfarin who require temporary interruption for a procedure

Periop Bridging Unnecessary for Most A-Fib Patients on Warfarin

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Arterial thromboembolism risk doesn't appear to rise without additional drug treatment
A proposal for identifying lower-cost generic biotech drugs has been released by the U.S. Food and Drug Administration.

FDA Issues Proposal on Lower-Cost, Generic Biotech Drugs

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All biotech drugs to carry a four-letter code to distinguish brand name, generic versions
Delay in epinephrine administration is associated with worse outcomes for children with in-hospital cardiac arrest with an initial nonshockable rhythm

Worse Outcomes for Children With Delay in Epinephrine

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Findings among cohort of children with in-hospital cardiac arrest with initial nonshockable rhythm
Antiviral drugs may help protect people from developing Ebola after exposure to the virus

Antiviral Rx May Help Prevent Ebola, Small Study Suggests

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Health care workers on antiviral regimen didn't develop disease after exposure
Discontinuing antihypertensive treatment in seniors with mild cognitive deficits does not improve mental functioning

No Cognitive Benefits Seen for Elderly Who Stop HTN Rx

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Prior research suggests lower BP increases risk for cognitive decline in elderly