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Clot Risk High With Oral Contraceptives for Those at Genetic Risk

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Risk highest in the first two years, regardless of genetic risk, and lower for continued use

Triptans, Ergots, Antiemetics Most Effective Meds for Migraine

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Individual medications with the highest odds ratios were eletriptan, zolmitriptan, and sumatriptan

Neratinib, Fulvestrant, Trastuzumab Combo Aids Metastatic Breast Cancer

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Three-drug combination beneficial for HR-positive HER2-mutant metastatic breast cancer with prior CDK4/6i therapy

Fluvoxamine Does Not Shorten Duration of COVID-19 Symptoms

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Findings observed among adults with mild or moderate COVID-19

Two-Week DAA Prophylaxis Prevents Hep C After Kidney Transplant

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Two-week DAA optimal for preventing infection in individuals without HCV viremia who received kidney from HCV-viremia-positive donors

Long-Term Exposure to ADHD Meds Linked to Increased Risk for CVD

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4 percent increase in risk for CVD seen in association with each one-year increase in ADHD meds across 14 years of follow-up

Disease-Modifying Therapy Use for Sickle Cell Remained Low 2014 to 2021

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Inconsistent users of DMT had higher prevalence of vaso-occlusive crises, splenic complications, health care visits

Ubrogepant Beneficial for Treating Migraine During the Prodrome

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Absence of moderate or severe headache reported in 46 and 29 percent of prodrome events that had been treated with ubrogepant, placebo

Publication Bias Inflates Apparent Efficacy of Alprazolam XR

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One of five trials in the FDA review was positive; all three trials in the published literature were positive

Recommendations Developed for Atopic Dermatitis Therapies

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Guidelines include strong recommendations for monoclonal antibodies and JAK inhibitors