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The addition of lixisenatide to usual care does not impact the rate of major cardiovascular events or other serious adverse events among patients with type 2 diabetes and a recent acute coronary syndrome

Lixisenatide Doesn’t Affect Cardiovascular Risk in T2DM

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Findings among patients with type 2 diabetes and recent acute coronary syndrome
Less frequent laboratory monitoring may be safe for patients receiving isotretinoin for acne as changes in mean values of several laboratory tests do not meet a priori criteria for high-risk

Evidence Doesn’t Support Monthly Labs With Isotretinoin

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Significant changes in values of several laboratory tests, but changes don't meet high-risk criteria
Clozapine reduces symptoms in patients with schizophrenia who don't benefit from other antipsychotic medications

Clozapine Benefits Those With Tx-Resistant Schizophrenia

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Clozapine already approved for use after other antipsychotics don't work
Acyclovir-induced neurotoxicity should be considered for patients with herpes zoster on hemodialysis

Neurotoxicity Seen With Acyclovir at Recommended Dose in Dialysis

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Case report describes acyclovir-induced neurotoxicity in patient treated with recommended dose
Drug-induced aseptic meningitis following trimethoprim use has been described in a research letter published online Nov. 20 in the International Journal of Rheumatic Diseases.

Trimethoprim-Induced Aseptic Meningitis Described

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Case report describes 87-year-old with 3 episodes; decreasing interval between dose, symptoms
Nearly half of Medicaid patients with chronic hepatitis C have been denied newer direct-acting antiviral medications

Expensive Hep C Drugs Denied to Almost Half of Medicaid Patients

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Most common reason for denial was "insufficient information to assess medical need"
Clinicians prescribing methylphenidate for treatment of attention-deficit/hyperactivity disorder in children and teens must weigh the benefits and adverse effects in the context of low-quality evidence

Low-Quality Evidence for Methylphenidate in ADHD

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Review highlights need for long-term, large, better-quality randomized trials
Between 2009 and 2015

Dermatologic Drug Prices Up Substantially From 2009

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Findings for brand-name meds; generics also increased substantially from 2011 to 2014
Physicians should prescribe generic medications whenever possible

ACP: Physicians Should Prescribe Generic Meds If Possible

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Brand name medications not superior to molecularly identical generic medications
The Bowel Function Index is a simple assessment tool for opioid-induced constipation

Bowel Function Index Valid for Opioid-Induced Constipation

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Three-item index is psychometrically valid, responsive to symptom severity