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A significant number of patients continue to take prescription opioids many months after joint replacement surgery

Many Still on Opioids Six Months After Total Joint Arthroplasty

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Study findings highlight growing epidemic
Diagnosis and management of heparin-induced thrombocytopenia are discussed in a review published in the May 31 issue of the Journal of the American College of Cardiology.

Vigilance Urged for Heparin-Induced Thrombocytopenia

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Heparin should be terminated on suspicion of HIT; alternative anticoagulants recommended
For patients receiving anti-epidermal growth factor receptor treatment

Prophylactic Antibiotics Cut Risk of Anti-EGFR Skin Rash

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Systematic review shows reduction in risk of developing a skin rash with prophylactic antibiotics
A decision tool (dual antiplatelet therapy [DAPT] score) improves risk prediction for continued DAPT beyond assessment of myocardial infarction history

DAPT Score Improves Risk Prediction of Continued DAPT

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Score improves prediction of benefit and harm for continued DAPT therapy beyond MI history alone
Betrixaban may be beneficial versus enoxaparin in acutely ill medical patients

Possible Benefit Found for Betrixaban in Acutely Ill

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No significant difference versus enoxaparin in prespecified primary efficacy outcome
Recognizing the unique role of patients and their expertise within the physician-patient interaction can help to prevent non-adherence based on disagreement

Recognition of Patient Expertise Can Improve Adherence

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Recognizing patient expertise in treatment decision can prevent nonadherence based on disagreement
For patients with rheumatoid arthritis

Prednisone Use Linked to Increased Risk of Mortality in RA

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Risk attenuated when patients are treated with combination of prednisone and methotrexate
Proton pump inhibitors increase the risk of nonsteroidal anti-inflammatory drug-induced small bowel injury

PPI Use Ups NSAID-Induced Small Bowel Injury

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Increased risk of small bowel injury for healthy participants treated with celecoxib + PPI
There is strong evidence to support intermittent inhaled corticosteroids for prevention of wheeze exacerbations in preschool children with intermittent asthma or viral-triggered wheezing

Intermittent Steroids Reduce Some Asthma Exacerbations

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Findings for preschool children with intermittent asthma or viral-triggered wheezing
Two new studies could pave the way to major changes in how severe cases of hemophilia are treated. Both studies were published in the May 26 issue of the New England Journal of Medicine.

New Findings Offer Hope for Those With Severe Hemophilia

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One study pinpoints when standard therapy works best; another uncovers the promise of a new drug