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Omalizumab is effective in patients with moderate-to-severe chronic spontaneous urticaria symptoms and angioedema unresponsive to high doses of antihistamine treatment

Omalizumab Effective for Chronic Spontaneous Urticaria

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Treatment improves quality of life, cuts angioedema recurrence
Oral estradiol therapy is associated with less progression of subclinical atherosclerosis in postmenopausal women when therapy is initiated early in menopause

Early Menopause Estradiol Tx Cuts Atherosclerosis Advance

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Positive effect seen only on carotid-artery intima-media thickness
Baricitinib

Baricitinib Superior to Placebo in Refractory Rheumatoid Arthritis

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Findings based on patients with previous inadequate response to biologics
The American College of Cardiology and the American Heart Association Task Force on Clinical Practice Guidelines has updated the recommendations regarding duration of dual antiplatelet therapy for patients with coronary artery disease. The updated practice guideline was published online March 29 in the Journal of the American College of Cardiology.

Guidelines Updated on Duration of Dual Antiplatelet Tx in CAD

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Longer-duration tx represents trade-off between decreased risk of cardiac events, increased bleeding
More than one in three older adults are given at least one potentially inappropriate prescription at the time of hospital discharge

Improper Prescribing Common at Hospital Discharge of Seniors

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Finding among older adults discharged from cardiology, internal medicine services
A new prediction rule may inform which patients will see a benefit or harm from dual antiplatelet therapy beyond one year after percutaneous coronary intervention

Tool Guides Duration of Dual Antiplatelet Therapy After PCI

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For patients without major bleed, ischemic event at one year after percutaneous coronary intervention
For patients with rheumatoid arthritis and a first non-tumor necrosis factor inhibitor failure

Tocilizumab Treats Rheumatoid Arthritis After Non-TNFi Failure

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Better efficacy for tocilizumab versus abatacept and rituximab in patients with first non-TNFi failure
Extended-release naltrexone is associated with a lower rate of opioid relapse than usual treatment among criminal justice offenders

Naltrexone ER Injection Cuts Opioid Relapse Rate in Inmates

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Lower rate of relapse compared with usual treatment in trial involving criminal justice offenders
The American College of Physicians has developed recommendations in order to address the escalating cost of prescription drugs

ACP Addresses Skyrocketing Costs of Prescription Medications

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ACP recommends transparency in relation to pricing, costs, and comparative value
Antipsychotic medications do not appear to be effective for preventing or treating delirium in adult medical or surgical inpatients

Antipsychotics Not Effective for Delirium in Hospitalized Patients

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No significant effect found for preventing or treating delirium during hospitalization