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For patients with moderate to severe diabetic peripheral neuropathic pain

Buprenorphine May Be Helpful in Peripheral Neuropathic Pain

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When tolerated, buprenorphine is effective for DPNP, but many patients withdrew from study
An experimental drug spurred substantial weight loss in patients with proopiomelanocortin deficiency

Drug Shows Promise for Genetic Proopiomelanocortin Deficiency

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After 10 months of daily treatment, one patient lost 112 lbs; another lost 45 lbs in three months
There are no significant differences in the associations between available glucose-lowering drugs (alone or in combination) and the risk of cardiovascular or all-cause mortality

Diabetes Meds Deemed Equal, but Metformin Still First-Line

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No significant differences in risk of cardiovascular or all-cause mortality
For pediatric patients

Biologic Response Modifier Use in Kids Ups Infectious Complications

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Risk varies with class of BRM; increased risk of mycobacterial, viral, fungal, opportunistic infections
Early initiation of antiretroviral therapy is associated with a sustained reduction in genetically-linked HIV-1 infections among sexual partners

Early Initiation of ART Cuts HIV-1 Infection in Partners

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Risk of genetically-linked partner infection 93 percent lower with early antiretroviral therapy
Metamizole seems to be safer than other nonsteroidal anti-inflammatory drugs and causes fewer gastric and duodenal ulcers in postoperative pain management

Metamizole Could Be Alternative to Classical NSAIDs

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Fewer gastric, duodenal ulcers with metamizole; limited risk of bleeding in post-op pain management
HIV transmission is highly unlikely among heterosexual couples who have sex without condoms when one partner carries the virus but takes antiretroviral therapy

Small HIV Infection Risk in Condomless Sex With Use of ART

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Study suggests transmission risk is low if infected person adheres to antiretroviral treatment
A drug used to treat leukemia

Nilotinib Shows Early Promise for Parkinson’s Disease

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Medication generally found safe, and study findings hint at a benefit
Recommendations for the use of antiretroviral therapy in HIV infection have been updated for adults

Recommendations Updated for Use of Antiretroviral Tx in HIV

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Preexposure prophylaxis for at-risk individuals; postexposure prophylaxis for after exposure
Emetine may represent a therapeutic option for human cytomegalovirus infection

Emetine Shows Promise for Human Cytomegalovirus Infection

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Inhibition with emetine occurs after virus entry but before DNA replication