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Arhalofenate (800 mg) is safe and significantly decreases gout flares compared to allopurinol (300 mg)

Arhalofenate Beats Allopurinol for Gout Flares

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Arhalofenate at an 800 mg dosage seems safe and well tolerated
Interferon-free direct-acting antiviral therapy is beneficial for hepatitis C virus-associated mixed cryoglobulinemia vasculitis

Interferon-Free, Tailored Tx Beneficial in HCV-Associated MC

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Guideline-tailored therapy highly effective, safe for hepatitis C virus-associated mixed cryoglobulinemia
The interaction between the organic cation transporter 1 and the serotonin reuptake transporter seems to play a role in metformin intolerance

OCT1, SERT Genes Play Role in Metformin Intolerance

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Intolerance up with low-expressing SERT S* alleles; multiplicative interaction for OCT1, SERT genotypes
Liraglutide added to capped insulin is associated with reductions in glycated hemoglobin

Liraglutide Added to Capped Insulin Reduces Hemoglobin A1c

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Liraglutide also significantly reduces mean body weight, daily insulin dose; increases quality of life
Twenty-four weeks of empagliflozin + metformin correlates with a significantly greater reduction in hemoglobin A1c compared with once-daily empagliflozin or twice-daily metformin

Greater Drop in Hemoglobin A1c With Empagliflozin + Metformin

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Greater reductions in HbA1c, weight compared to empagliflozin or metformin alone
Patients who receive early treatment for symptoms consistent with the onset of multiple sclerosis are about one-third less likely to eventually be diagnosed with multiple sclerosis than participants whose treatment is delayed

Long-Term Benefit Seen for Early Treatment of MS Symptoms

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Industry-funded study also found therapy doubled time until a relapse occurred
In patients with high-risk relapsed/refractory acute myelogenous leukemia (AML) or untreated AML unfit for intensive chemotherapy

Venetoclax Monotherapy Active in AML With Adverse Features

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Overall response rate 19%; additional 19% have antileukemic activity without meeting IWG criteria
Alitretinoin treatment aids in normalizing expression of barrier genes and proteins in patients with chronic hand eczema

Alitretinoin Cuts Chronic Hand Eczema Severity

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Treatment seems to normalize expression of skin barrier genes, proteins
For women undergoing urogynecologic surgery

Polyethylene Glycol 3350 Doesn’t Cut Time to Bowel Movement

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Addition of PEG3350 to docusate sodium cuts use of additional laxatives, increases drug adherence
Intravenous immunoglobulin is increasingly being used for interstitial lung disease

IV Immunoglobulin Use Up in Interstitial Lung Disease

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No studies support use of IVIg in ILD, but increasingly being used off-label for refractory cases