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First-line therapy for patients with low back pain should be simple non-pharmacological remedies -- from heat wraps to physical therapy

ACP Issues Guideline for Treating Acute, Subacute, Chronic LBP

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Recommendations state opioids should be last resort for pain
For patients with rheumatoid arthritis

Short-Course Tocilizumab May Up Hep B Reactivation in RA

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Three patients with chronic HBV infection had reactivation, but they were asymptomatic
There has been a sharp rise in the number of American seniors who take three or more medications that affect their central nervous system

Use of Multiple CNS-Affecting Drugs Increasing Among Seniors

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Psychiatrist cautions doctors and patients to consider risks and benefits of each drug
Sending medication adherence reminders following fresh-start dates (life and calendar events indicating the start of new cycles) is not effective for increasing medication adherence

Rx Adherence Reminders No More Effective at ‘Fresh Start’ Dates

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No difference in proportion of days covered for birthday, new year reminders vs control reminder
Concomitant use of valproic acid and meropenem is associated with a decrease in valproic acid plasma levels

Valproic Acid Plasma Levels Down With Concomitant Meropenem

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Concomitant use of meropenem linked to decrease in VPA plasma level, regardless of MEPM dose
Intravenous lidocaine seems safe for reducing pain among patients in the intensive care unit with varying degrees of organ dysfunction

Intravenous Lidocaine Offers Alternative for ICU Patients’ Pain

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Findings in patients in intensive care unit with varying degrees of organ dysfunction
In response to revised osteoporosis recommendations in 2008

Shift in Bisphosphonate Tx After 2008 Recommendations

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From 2008 to 2012, drop in proportion of younger women, increase in women aged ≥65 years
For patients with type 2 diabetes

Novel Oral Glucose Lowering Drugs Cut Risks in T2DM

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Reduced risk of all-cause mortality and CVD with dapagliflozin; lower risk of mortality with DPP-4i
For patients with Clostridium difficile infection

30-day Mortality Down With Vancomycin in C. difficile

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But Clostridium difficile recurrence rate similar for metronidazole, vancomycin
Prescribing practices vary among U.S. and Canadian physicians treating severe childhood atopic dermatitis

Variation in Prescribing Practices for Pediatric Atopic Dermatitis

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For severe AD, first-line drugs of choice include cyclosporine, methotrexate, mycophenolate mofetil