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Glucarpidase Improves Outcomes in Patients With Methotrexate-Induced Kidney Toxicity

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Glucarpidase associated with 2.70-fold increased odds of kidney recovery in methotrexate-acute kidney injury

Adjuvant Trastuzumab Emtansine Improves Overall Survival in HER2+ Breast Cancer

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T-DM1 sustained the improvement in invasive disease-free survival over trastuzumab in HER2-positive early breast cancer

Differences Exist in Precision Oncology Drug Eligibility Among Patient Ancestral Groups

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Patients of African ancestry had the lowest precision oncology drug-based clinical actionability from 2019 onward

MEK Inhibition Beneficial for Children With Subset of Severe Hypertrophic Cardiomyopathy

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Decrease in mortality, morbidity seen with trametinib for children with RASopathy-associated hypertrophic cardiomyopathy

Polypill Treatment Offers High Value in Low-Income, Underserved Population

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Polypill treatment estimated at $8,560 per QALY gained compared with usual care and had high value in 99 percent of simulations

Some Maternal Medications Lower Levels of Protein, Fat in Breastmilk

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Significantly lower protein levels seen with SSRIs and steroids; mean fat lower for mothers with other anti-inflammatory drugs

Talquetamab Plus Teclistamab Shows Promise in Multiple Myeloma

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Grade 3 or 4 adverse events occurred in 96 percent of patients; grade 3 or 4 infections occurred in 64 percent

Eight in 10 Infants Received RSV Protection in the 2023 to 2024 Season

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Findings seen within a single health care system during the early period of availability

Denosumab Increases Cardiovascular Risk in Dialysis-Dependent Patients

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Denosumab has greater preventive effect on fractures, but increased risk for MACE compared with oral bisphosphonates

Incident Gabapentin Use Not Linked to Increase in Falls Versus Duloxetine

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Findings seen in older adults with diabetic neuropathy, postherpetic neuralgia, or fibromyalgia