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Trametinib Safe, Effective for Juvenile Myelomonocytic Leukemia

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Seven of 10 children with relapsed or refractory JMML completed all 12 cycles of therapy or used trametinib as bridge to HSCT

Lebrikizumab Tied to Sustained Atopic Dermatitis Treatment Effect

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Findings seen despite negligible remaining lebrikizumab serum concentrations following treatment withdrawal

Continuing Metformin in Pregnancy Has Little Effect on Nonlive Birth

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Little to no increased risk for nonlive birth seen among women continuing metformin and adding insulin versus switching to insulin monotherapy

Paternal Metformin Use Not Linked to Major Congenital Malformations

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No significant association seen for increased risk for MCMs with metformin in monotherapy, but association suggested for metformin in polytherapy

2008 to 2021 Saw Increase in Prevalence of Chronic HTN in Pregnancy

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During study period, use of antihypertensive medications was relatively stable for those with chronic hypertension

Few Receive Meds for Opioid Use Disorder After Nonfatal Overdose

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Lower odds of fatal OD seen with filling naloxone prescription, receiving methadone or buprenorphine, receiving behavioral health assessment or crisis services

No Link Seen Between Exposure to Immunosuppressive Therapy, Cancer in IBD Patients

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No significant association seen between immunosuppression receipt and incident cancer after adjustment for confounders

ENDO: Teprotumumab Shows Long-Term Efficacy for Thyroid Eye Disease

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Inflammatory and ophthalmic composite outcome improvements seen in 90 percent of patients at 72 weeks

Several Drugs Linked to Risk for Aneurysmal Subarachnoid Hemorrhage

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aSAH risk increased in association with current use of warfarin, venlafaxine, prochlorperazine, and co-codamol

Smoking Cessation Aids Equally Effective in Those With Mental Health Conditions

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Specifically, vaping products, varenicline, and heated tobacco products tied to significantly greater odds of successful cessation