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ADHD Meds May Help Control Opioid Use Disorder in Pregnancy

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Additional benefits include increased buprenorphine initiation, decreased methadone initiation, and improved buprenorphine retention

SNP rs13194504 AA Genotype Linked to Severity of Tardive Dyskinesia

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AA genotype linked to reduced severity, but not occurrence, of TD; no association seen for rs210133 with TD occurrence, severity

Nonsignificant Survival Benefit Seen for Dabrafenib, Trametinib in Melanoma

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Consistent survival benefit seen across several prespecified subgroups, including those with a BRAF V600E mutation

Timing of Metformin Important in Metformin-Treated Type 2 Diabetes

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Glucose lowering is greater when metformin is given before rather than with enteral glucose; this is also linked to greater GLP-1 response

Improved Outcomes Seen With Ibrutinib in Chronic Lymphocytic Leukemia

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Time to next treatment was improved for first-line ibrutinib versus chemoimmunotherapy in match-adjusted analyses

Angiotensin Receptor Blocker Use Linked to Lower Incidence of Epilepsy

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Findings seen in patients with no preexisting history of stroke or cardiovascular disease in subgroup analyses

ViPOR Results in Durable Remission in Specific Subtypes of Lymphoma

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Complete responses seen in 38 percent of patients, all with non-GCB DLBCL, high-grade B-cell lymphoma with rearrangements of MYC and BCL2 or BCL6

Reteplase Superior to Alteplase Within 4.5 Hours of Ischemic Stroke

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Reteplase more likely to result in excellent functional outcome than alteplase for ischemic stroke within 4.5 hours of symptom onset

FDA Approves Augtyro for NTRK-Positive Advanced Solid Tumors

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Approval is for both TKI-naive and TKI-pretreated patients across solid tumor types

Dementia With Lewy Bodies Risk Down With α-1 Adrenergic Receptor Antagonists

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Risk for developing DLB was lower for men newly started on Tz/Dz/Az compared with those taking tamsulosin or 5ARI