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Survival Up With Nivolumab + Ipilimumab Versus Chemo for Metastatic CRC

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Findings seen in patients with microsatellite-instability-high or mismatch-repair-deficient metastatic colorectal cancer

Radiotherapy With Adjuvant Durvalumab No Benefit for Head, Neck Cancer

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No improvement seen in two-year progression-free survival for radiotherapy with durvalumab versus radiotherapy with cetuximab

Itacitinib Helps Prevent Graft Versus Host Disease in Stem Cell Transplant Recipients

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Itacitinib results in low cytokine release syndrome grades, low incidence of acute, chronic graft versus host disease

Deprescribing Antihypertensives Not Tied to Hospitalization for Heart Attack, Stroke

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Estimated unadjusted cumulative incidence did not differ between long-term care residents who were deprescribed or continued antihypertensives

Two Common Antiseizure Medications Do Not Harm Child Neurodevelopment

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No differences seen in six-year verbal abilities for children exposed, unexposed to antiseizure medications in utero

Incidence of HIV Lower With Twice-Yearly Subcutaneous Lenacapavir

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HIV incidence was significantly lower with lenacapavir than daily oral emtricitabine-tenofovir disoproxil fumarate

Discontinuing Cholinesterase When Starting Memantine Not Tied to Institutionalization Care

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Discontinuation tied to lower risk for fall-related injury

Sodium Oxybate Beneficial for Alcohol-Responsive Laryngeal Dystonia

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Clinically meaningful improvement seen in symptoms; drug efficacy waned by 300 minutes, with no rebound

AHA: Variation Seen in Rates of SGLT2i Rx for Heart Failure, LVEF >40 Percent

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Prescription rates increased from 2021 to 2023, but high variance seen between hospitals in the rate of prescriptions

In Utero Exposure to Certain Antiepileptics Tied to Neurodevelopmental Diagnoses

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Children exposed to topiramate were 2.5 times more likely to be diagnosed with intellectual disability