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Breast Surgery Can Be Omitted After Neoadjuvant Systemic Therapy in Select Patients

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Patients with initial nodal metastases and breast pCR on vacuum-assisted biopsy who underwent targeted axillary dissection had axillary pCR

AAN: Tolebrutinib Slows Disability in Nonrelapsing Secondary Progressive MS

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Tolebrutinib treatment associated with 31 percent risk reduction in six-month confirmed disability progression versus placebo

AAN: Tavapadon as Adjunct to Levodopa Ups Daily ON Time in Parkinson Disease

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Significant reduction also seen in change from baseline in daily OFF times versus placebo

Alteplase Increases Frequency of Functional Independence After Posterior Circulation Stroke

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Findings seen in patients with posterior circulation stroke and with no planned thrombectomy who received alteplase 4.5 to 24 hours after stroke onset

Prevalence of Prescription Stimulant Misuse High in U.S. Adults

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Higher prevalence ratios for misuse, prescription stimulant use disorder seen for those using amphetamines versus methylphenidate

FDA Approves Cabozantinib for Previously Treated Advanced Neuroendocrine Tumors

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Patients treated with cabozantinib survived significantly longer with no worsening of their disease compared with patients who received placebo

Pelabresib Plus Ruxolitinib Improves Underlying Myelofibrosis

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In a recent study, significantly more patients receiving the combination therapy met primary end point of reduction in spleen volume of ≥35 percent from baseline

Heart Failure Patients With Ejection Fraction Improvement Rarely Withdrawn From Meds

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Withdrawing renin-angiotensin inhibitors/angiotensin receptor-neprilysin inhibitors and mineralocorticoid receptor antagonists tied to higher one-year mortality, morbidity

Molecular Residual Disease Analysis May Predict Disease Recurrence After Lung Cancer Resection

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Molecular residual disease precedes DFS events in patients receiving osimertinib, placebo; most events occur after osimertinib discontinuation or completion

Long-Term Gantenerumab May Slow Decline in Dominantly Inherited Alzheimer Disease

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Hazard ratio for clinical decline in Clinical Dementia Rating-Sum of Boxes was 0.53 for those treated with gantenerumab the longest