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Tag: Parkinson’s

Predictors of neurodegeneration from idiopathic REM sleep behavior disorder have been identified

Conversion From Sleep Disorder to Neurodegeneration Studied

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Predictors include abnormal quantitative motor testing, MCI, olfactory deficit, motor symptoms
For patients with early Parkinson disease

Levodopa + Carbidopa Does Not Modify Disease in Early Parkinson

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Findings in patients with early Parkinson disease evaluated over the course of 80 weeks
There is no correlation between urate and blood pressure in mice or among patients with early Parkinson's disease

Urate Elevation in Potential Tx for Parkinson’s Not Tied to HTN

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Phase II clinical trial results, mouse model study show no link between serum urate, changes in BP
For patients with Parkinson's disease undergoing gene therapy

Gene Therapy Forms New Polysynaptic Pathways in Parkinson’s

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Patients receiving GAD gene therapy develop unique treatment-dependent polysynaptic brain circuit
Patients with idiopathic parkinsonism have reduced survival

Reduced Survival for Patients With Idiopathic Parkinsonism

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Mild cognitive impairment, freezing of gait, elevated leukocytes in CSF tied to shorter survival
The normal human appendix seems to contain pathogenic forms of α-synuclein

Removing Appendix May Lower Risk for Parkinson’s Disease

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Healthy human appendix contains intraneuronal α-synuclein aggregates, truncation products
One in two women and one in three men will develop dementia

Half of Women to Develop Stroke, Dementia, or Parkinsonism

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Third of men to develop at least one of these; women more likely to experience both stroke and dementia
A sensor array has the potential to identify de novo Parkinson's disease patients with high sensitivity

Sensor Array May Detect De Novo Parkinson’s Disease in Breath

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Sensitivity, specificity, accuracy values of 79, 84, and 81 percent for detecting PD from controls
For patients with Parkinson's disease

Parkinson’s Medications Tied to Impulse Control Disorders

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Impulse control disorders strongly associated with dopamine agonist use
There is an increased rate of subsequent Parkinson's disease among individuals diagnosed with type 2 diabetes mellitus

Strong Link Identified Between T2DM and Parkinson’s Disease

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Findings in large cohort study based in the United Kingdom