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Subcutaneous botulinum toxin type A injections appear to safely and effectively reduce chronic neuropathic pain in patients with spinal cord injury

Botox May Reduce Chronic Neuropathic Pain

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Findings in small study of patients with spinal cord injury-associated pain
Taking prescription opioids doesn't improve movement or reduce disability for patients with neuropathic pain

Opioids Don’t Ease Disability in Neuropathic Pain

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Medications aren't useful in restoring motion, researchers say
U.S. researchers are challenging a leading theory about the nation's heroin epidemic

Pathway to Heroin Described in NEJM Commentary

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Initial exposure to opioids appears to 'push' potential addicts to heroin
Exposure to opioids is associated with increased likelihood of low testosterone levels

Opioid Exposure Tied to Higher Odds of Low Testosterone Levels

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Increased odds of low testosterone with exposure; increased odds with increasing age, comorbidities
Patients with a nonfatal opioid overdose are almost always prescribed opioids after overdose

After Nonfatal Overdose, Most Patients Prescribed More Opioids

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Cumulative incidence of repeated overdose 17 percent for those receiving high doses after overdose
The top 10 percent of Medicare prescribers account for more than 50 percent of opioid claims

Distribution of Opioid Prescribing ID’d for Different Providers

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Top 10 percent of Medicare prescribers account for 56.7 percent of opioid claims
Mental disorders seem to be associated with chronic pain in adolescents

Mental Disorders Associated With Chronic Pain in Teens

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Most substantial temporal links for affective, anxiety, and behavior disorders prior to chronic pain
Conventional non-pharmacologic and pharmacologic options for the management of opioid-induced constipation in pregnancy are often ineffective or cause potentially troublesome adverse effects

Opioid-Related Constipation Tx Suboptimal in Pregnancy

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PAMORA strategy appears to safe with superior effectiveness
For patients with knee osteoarthritis

Leg Muscle Power Predicts Pain, Quality of Life in Knee OA

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Muscle power, but not strength, is independent determinant of pain and quality of life
X-rays don't detect hip osteoarthritis in many patients

Radiographs Not Picking Up Osteoarthritis in Hip

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Researchers found osteoarthritis in fewer than one-quarter of images in high clinical suspicion cases