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Tag: Osteoporosis

The risk for bone loss rises sharply in young breast cancer patients who received standard treatment

Young Breast Cancer Patients Face Higher Risk for Osteoporosis

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Women diagnosed before age 50 have twice the risk versus cancer-free peers
Denosumab

Denosumab Promising for TDT-Induced Osteoporosis Treatment

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Higher percentage increase of L1 to L4 and wrist bone mineral density with DMN, reduction in pain
In recent years there have been low rates of osteoporosis treatment initiation after a hip fracture

Drop in Osteoporosis Treatment Initiation After Hip Fracture

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Adherence to regimen needed to cut subsequent fracture risk
The U.S. Preventive Services Task Force recommends screening for osteoporosis to prevent fractures for women aged ≥65 years and for postmenopausal women aged <65 years at increased risk of osteoporosis. These findings form the basis of a final recommendation statement published online June 26 in the Journal of the American Medical Association.

USPSTF Favors Osteoporosis Screening to Prevent Fracture

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Screening with bone measurement recommended for women aged ≥65, younger women at risk
For patients with osteopenia or osteoporosis

Fx Risk Should Be Monitored in Bisphosphonate Drug Holiday

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Lower femoral neck bone mineral density and T scores for fracture versus non-fracture group
The U.S. Preventive Services Task Force draft recommendation statement and draft evidence review on Screening for Osteoporosis to Prevent Osteoporotic Fractures have been posted for public comment through Dec. 4

USPSTF Posts Osteoporosis Screening Recommendations

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All women ≥65, high-risk postmenopausal women <65 should undergo bone measurement testing
Combined assessment of bone strength and bone mineral density is a cost-effective strategy for osteoporosis screening in postmenopausal women

Bone Strength + Bone Mineral Density Screening Cost-Effective

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Model shows this combo starting at age 55 in postmenopausal women prevents fractures
Osteoporotic fractures and complications of diabetes similarly impact quality of life

Effect of Osteoporotic Fractures Similar to Diabetes Burden

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Findings for quality of life with hip fractures, vertebral compression vs. vision loss, amputation
Romosozumab treatment followed by alendronate is linked to reduced risk of fractures versus alendronate alone for postmenopausal women with osteoporosis

ASBMR: Romosozumab Reduces Fracture Rate in Osteoporosis

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Reduced risk of new vertebral fractures, nonvertebral fractures for romosozumab and alendronate
The prevalence of vertebral fracture varies for different methods of radiological assessment

Prevalence of Vertebral Fracture Varies With Assessment Method

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Significantly different prevalence for quantitative morphometry, algorithm based qualitative methods