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Immediate access to opioid agonist treatment for patients presenting with opioid use disorder may provide greater health benefits at less cost than observed standard of care

Immediate Access to Opioid Agonists Found Cost-Effective

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Findings among patients with opioid use disorder in publicly-funded treatment facilities
Individuals born between 1947 and 1964 have a significantly increased risk of prescription opioid overdose death and heroin overdose death

Baby Boomers Have Increased Risk of Rx Opioid Overdose Death

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In addition, those born from 1947 to 1964 and 1979 to 1992 have increased risk of heroin overdose death
The U.S. Food and Drug Administration investigation into the safety of codeine use by children

FDA Investigation Linked to Drop in Codeine Rx for Children

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But 1 in 20 patients undergoing tonsillectomy and/or adenoidectomy still prescribed codeine
Although initiation of extended-release naltrexone (XR-NTX) may be more difficult

XR Naltrexone, Sublingual BUP-NX Deemed Equally Effective

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Difficulty initiating XR-NTX accounts for difference in relapse rates in intent-to-treat population
Patients use a mean of 8.7 of the initially prescribed 20 to 30 hydrocodone-acetaminophen combination tablets after rhinoplasty

Surgeons Often Prescribing Too Many Opioids After Rhinoplasty

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Patients use a mean of 8.7 tablets, only 40 percent of the number prescribed after rhinoplasty
Gynecologists prescribe about twice the amount of opioids than patients use after hysterectomy for benign

Patients Use ~Half of Opioids Prescribed After Hysterectomy

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Pre-op Fibromyalgia Survey score, overall body pain, pre-op opioid use, abdominal sx predict opioid use
For patients presenting to the emergency department with acute extremity pain

In ER, Combination of Ibuprofen, Acetaminophen Relieves Pain

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No difference in pain reduction for ibuprofen and acetaminophen vs. 3 opioid/acetaminophen combos
For patients with rheumatoid arthritis

ACR: Opioids, SSRIs Tied to Higher Fracture Risk in RA

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Increased risk of osteoporotic fracture with selective serotonin reuptake inhibitors, opioids of any strength
Fentanyl was involved in more than half of opioid overdose deaths reported in the second half of 2016

Fentanyl or Analogs Tied to More Than Half of All Opioid Deaths

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And 57 percent of fentanyl-related deaths also tested positive for other drugs, such as heroin
Opioid-free anesthesia is feasible and well-tolerated

ASA: Opioid-Free Anesthesia Feasible for Surgical Procedures

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Only 36 percent of patients request oral opioid meds in PACU despite receiving opioid-free anesthesia