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Although initiation of extended-release naltrexone (XR-NTX) may be more difficult

XR Naltrexone, Sublingual BUP-NX Deemed Equally Effective

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Difficulty initiating XR-NTX accounts for difference in relapse rates in intent-to-treat population
Patients use a mean of 8.7 of the initially prescribed 20 to 30 hydrocodone-acetaminophen combination tablets after rhinoplasty

Surgeons Often Prescribing Too Many Opioids After Rhinoplasty

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Patients use a mean of 8.7 tablets, only 40 percent of the number prescribed after rhinoplasty
Gynecologists prescribe about twice the amount of opioids than patients use after hysterectomy for benign

Patients Use ~Half of Opioids Prescribed After Hysterectomy

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Pre-op Fibromyalgia Survey score, overall body pain, pre-op opioid use, abdominal sx predict opioid use
For patients presenting to the emergency department with acute extremity pain

In ER, Combination of Ibuprofen, Acetaminophen Relieves Pain

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No difference in pain reduction for ibuprofen and acetaminophen vs. 3 opioid/acetaminophen combos
For patients with rheumatoid arthritis

ACR: Opioids, SSRIs Tied to Higher Fracture Risk in RA

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Increased risk of osteoporotic fracture with selective serotonin reuptake inhibitors, opioids of any strength
Fentanyl was involved in more than half of opioid overdose deaths reported in the second half of 2016

Fentanyl or Analogs Tied to More Than Half of All Opioid Deaths

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And 57 percent of fentanyl-related deaths also tested positive for other drugs, such as heroin
Opioid-free anesthesia is feasible and well-tolerated

ASA: Opioid-Free Anesthesia Feasible for Surgical Procedures

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Only 36 percent of patients request oral opioid meds in PACU despite receiving opioid-free anesthesia
For patients undergoing total knee or hip arthroplasty

ASA: Fewer Opioids Being Used for Post-Op Pain After TKA, THA

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Increase in proportion of patients receiving one, two, more than two analgesic modes
Extended-release naltrexone is noninferior to buprenorphine-naloxone for maintaining short-term abstinence from heroin and other illicit substances

Extended-Release Naltrexone Promising for Opioid Dependence

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Lower use of heroin, other illicit opioids with extended-release naltrexone in superiority analysis
For patients using chronic opioids

ACG: Diphenhydramine Ups Sedation in Chronic Opioid Users

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Improvement in sedation scores for patients using chronic opioids scheduled to undergo colonoscopy