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Prenatal opioid exposure is negatively associated with neurocognitive and physical development in offspring from the age of 6 months into school age

Prenatal Opioid Exposure Harms Long-Term Child Development

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Negative effects on cognitive, motor outcomes seen from age 6 months persist to school age
Overall

About 12 Percent With Ankle Sprain Fill Opioid Prescriptions

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Among opioid-naive patients, 8.4 percent of those who filled an initial opioid Rx had persistent use
The vast majority of orthopedic surgeons recommend prescribing a nine-day supply of around-the-clock oxycodone doses following commonly performed orthopedic surgeries

Survey Reveals Gaps in Opioid Rx Patterns of Orthopedic Surgeons

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History of drug misuse, depression did not necessarily diminish hypothetical prescribing rates
In utero exposure to opioids is associated with higher risks for short- and long-term adverse outcomes

In Utero Opioid Exposure Tied to Poor Outcomes Throughout Childhood

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Adverse outcomes seen at birth and in preschool and school-aged children
Patients undergoing partial knee replacement have a reduced risk for venous thromboembolism and opioid use in months 3 to 12 after surgery

VTE Risk Reduced With Partial Knee Replacement

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But risk for five-year revision higher for those undergoing partial versus total knee replacement
Specific patterns of opioid administration to opioid-naive inpatients are associated with risk for long-term use after discharge

Patterns of Inpatient Opioid Use Linked to Long-Term Use

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Outpatient use at 90 days was seen for 5.9 and 3.0 percent of patients with and without inpatient use
Following implementation of an opioid-sparing pain management strategy

Opioid-Sparing Strategy Still Provides Good Pain Control

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Patients surveyed following surgery and only a small 'rescue' opioid Rx postop
The rates of prolonged opioid prescribing remain high for older cancer survivors five or more years after cancer diagnosis

Long-Term Opioid Prescribing Up Among Older Cancer Survivors

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Cancer survivors diagnosed 2004 to 2008 have higher rates of opioid prescribing versus those diagnosed earlier
Prescription opioid misuse is more common among binge drinkers

Prescription Opioid Use Up Among Binge Drinkers

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More than half of those who misused prescription opioids in 2012 to 2014 were binge drinkers
The Opioid Safety Initiative has been effective for decreasing opioid prescriptions among patients undergoing total knee arthroplasty

Opioid Safety Initiative Can Decrease Opioid Prescriptions

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Reduction seen in opioid prescriptions among patients undergoing total knee arthroplasty