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The interaction between antibiotics and human growth and obesity is explored in a historical perspective piece published in the Jan. 17 issue of the Annals of Internal Medicine.

Interaction Between Antibiotics, Obesity Is Complex

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Since the 2000s, attention has turned toward understanding role of abx, microbiome in obesity
Overweight and obese children seem to be more likely than others to develop postoperative surgical site infections

Risk of Post-Op Infections Up in Overweight, Obese Children

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Surgical site infections more common for overweight or obese patients
Resistance to the antilipolytic effect of insulin is increased in obese individuals with normal glucose tolerance

Adipose Tissue Insulin Resistance Up in Obese-NGT, IGT, T2DM

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Progressive decline in β-cell function linked to progressive impairment of free fatty acid suppression
For obese patients with asthma

Exercise + Weight Loss Improves Asthma Control in Obese

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Addition of exercise to weight-loss program also improves lung function, inflammatory biomarkers
Weight-loss surgery helps severely obese teens maintain weight loss over the long term; however

Very Obese Teens Benefit From Gastric Bypass Over Long Term

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Studies show most maintain significant weight loss over five years, but complications emerge for some
For overweight/obese patients with compensated cirrhosis and portal hypertension

Lifestyle Intervention Reduces Portal Pressure in Cirrhosis

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Reduction in body weight and portal pressure with 16-week intervention in compensated cirrhosis
Maternal and paternal obesity are associated with delays in early childhood development

Maternal, Paternal Obesity Tied to Childhood Development Delays

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Having both parents with BMI ≥35 kg/m² linked to likelihood of failing problem-solving domain
Evidence-based recommendations have been developed for screening

Recommendations Developed for Pediatric NAFLD

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Recommendations relate to screening, diagnosis, treatment, and long-term care of pediatric NAFLD
Many patients with obesity

Many Obese Patients Are Lacking Formal Diagnosis

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Less than 50 percent of those with a BMI >30 kg/m² have ICD-9 documentation for obesity
Doctors should screen children age 6 years and older for obesity

USPSTF Reaffirms Obesity Screening Recs for Children 6+

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U.S. Preventive Services Task Force fine-tunes 2010 recommendation