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Warning letters about products illegally marketed as treatments for opioid addiction

FDA Warns Two Companies About Bogus Opioid Addiction Treatment

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Tianeptine-containing dietary supplements can pose a number of health risks
Omega-3 fatty acids and vitamin D do not significantly reduce major cardiovascular events or cancer incidence

AHA: Limited Benefit for n-3 Fatty Acids in CVD, Cancer Prevention

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Second study shows no significant results for vitamin D supplementation versus placebo
Many supplements contain one or more stimulants that have been the subject of U.S. Food and Drug Administration-issued public notices

Most Supplements Contain Prohibited Stimulants

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75 percent of supplements purchased in 2017 contained one or more stimulants subject to FDA notices
Dietary supplements often include active pharmaceuticals

Active Pharmaceuticals ID’d in >700 Dietary Supplements

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More than 20 percent of the 776 adulterated products contained more than one unapproved ingredient
Supplementation with folic acid beyond the first trimester does not prevent preeclampsia among high-risk women

Folic Acid Past First Trimester Doesn’t Prevent Preeclampsia

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Supplementation beyond first trimester does not reduce risk of preeclampsia in high-risk women
Supplementation with n-3 long chain polyunsaturated fatty acids in pregnancy leads to higher body mass index in offspring at age 6 years

Adding Fish Oil in Pregnancy May Lead to Higher Child BMI

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Supplementation linked to higher BMI z score at age 6 years but no higher proportion of obese children
Approximately one-third of U.S. children and adolescents use dietary supplements

One-Third of U.S. Children, Teens Use Dietary Supplements

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Trend shows growing use of alternative medicines, including melatonin, ω-3 fatty acids
Hypertensive patients may lower their stroke risk with folic acid supplements

Folic Acid May Cut Stroke Risk in High-Risk Hypertensive Patients

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Findings among patients with low platelet count, high homocysteine levels
The U.S. Preventive Services Task Force concludes that exercise interventions may be beneficial for preventing falls in older adults; however

USPSTF: Exercise Interventions Prevent Falls in Seniors

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Second recommendation statement finds evidence lacking for benefit of calcium, vitamin D, or both
Supplementation with n-3 fatty acids is not associated with significant benefit in dry eye disease

n-3 Fatty Acids Don’t Seem to Be of Any Benefit in Dry Eye Disease

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Patients randomized to n-3 supplementation did not have significantly better outcomes versus placebo