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Tag: Muscle Problems

The burden of musculoskeletal diseases increased significantly worldwide between 2000 and 2015

Global Burden of Musculoskeletal Diseases on the Rise

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Significant increases seen worldwide, but burden highest in Europe
Limited evidence suggests that nusinersen treatment provides long-term benefits for children with later-onset spinal muscular atrophy

Nusinersen Promising for Later-Onset Spinal Muscular Atrophy

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Phase 1/2 studies reveal long-term improvement in motor function for children with SMA type II and III
ZRT- and IRT-like protein 14 upregulation in skeletal muscles may play a role in cancer-related muscle loss

Excess Zinc in Muscles May Drive Cancer-Related Wasting

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ZIP14 may be a therapeutic target for its treatment
In a case report published online June 18 in BMJ Case Reports

Tattoo-Linked Complications ID’d in Immunosuppressed Female

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Inflammatory myopathy identified in woman with cystic fibrosis on long-term immunosuppressants
For infants with type 1 spinal muscular atrophy who have two copies of the survival motor neuron (SMN) 2 gene

AAN: New Drug May Help Infants With Spinal Muscular Atrophy

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RG7916 increases survival motor neuron protein level, with 6.5-fold increase noted with highest dose
For infants with type 1 spinal muscular atrophy who have two copies of the survival motor neuron (SMN) 2 gene

AAN: New Drug May Help Infants With Spinal Muscular Atrophy

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RG7916 increases survival motor neuron protein level, with 6.5-fold increase noted with highest dose
Physically active young adults with type 1 diabetes have alterations in mitochondrial ultrastructure and bioenergetics within skeletal muscle

Young Adults With T1DM Show Muscle Metabolic Deficiencies

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Lower mitochondrial oxidative capacity in skeletal muscle of physically active young adults with T1DM
Nusinersen is associated with significant and clinically meaningful improvement in motor function among children with later-onset spinal muscular atrophy

Nusinersen Beneficial in Later-Onset Spinal Muscular Atrophy

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Significant improvement in motor function compared with sham procedure among children with SMA
The prevalence of work-related musculoskeletal disorders appears to be high for at-risk physicians

Higher Risk of Musculoskeletal Disorders in Some Physicians

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Increasing risk for work-related musculoskeletal disorders, particularly in procedural specialists
New classification criteria have been developed for idiopathic inflammatory myopathies

Criteria Developed for Idiopathic Inflammatory Myopathies

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Classification criteria developed from rheumatology, dermatology, neurology, pediatric clinic data