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Midlife Deaths of Despair Increased From 1999 to 2022

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Particularly large increases were seen for American Indian or Alaska Native and Black individuals

ACC: Empagliflozin Does Not Cut Risk for Heart Failure After Acute MI

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No reduction in risk for first hospitalization for heart failure or death seen among patients at increased risk for heart failure

Salt Substitution May Reduce All-Cause, Cardiovascular Mortality

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Slight reduction seen in major cardiovascular events; very low certainty of serious adverse events reported

Single Invitation for PSA Screening Cuts Prostate Cancer Deaths

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Small, but significant reduction seen in prostate cancer deaths, but no reduction seen in all-cause mortality

Number of Prostate Cancer Cases Set to Increase to 2.9 Million in 2040

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Large increases in prostate cancer expected due to changing age structure and improving life expectancy

Delirium Increases Risk for Subsequent Death, Dementia in Older Adults

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Dose-response association seen with higher risk for each additional delirium episode

Polybrominated Diphenyl Ether Linked to Increased Risk for Cancer Mortality

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About 300 percent increased risk seen for those in highest versus lowest tertile of serum PBDE levels

Up to 30 Percent of CVD Mortality Attributable to Excess Salt Intake

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Population-attributable risk estimates suggest sodium above recommended intake linked to 10 to 30 percent of CVD mortality

Global Adult Mortality Rates Increased During COVID-19

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Increase seen during pandemic period, following decrease between 1950 and 2019; child mortality continued to drop during pandemic

Time-Restricted Eating Linked to Cardiovascular Mortality

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Eating duration of less than eight hours linked to increased risk for CV mortality overall and for those with CVD and cancer