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Tag: Lyrica

Nine drug companies have received approval for the first generic versions of Lyrica (pregabalin)

FDA Grants First Approvals for Generic Versions of Lyrica

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Generic versions approved for neuropathic pain management, fibromyalgia, partial onset seizures
Gabapentinoids are associated with increased risks for adverse outcomes related to coordination disturbances

Gabapentinoids Linked to Increased Risk for Significant Adverse Outcomes

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Risk increased for suicidal behavior, unintentional overdose, road traffic incident, head/body injuries
Concomitant exposure to pregabalin and opioids is associated with increased odds of opioid-related death

Odds of Death Up With Exposure to Pregabalin, Opioids

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Dose-response association with highest odds of opioid-related death with high-dose pregabalin
Pregabalin does not significantly reduce the intensity of leg pain associated with sciatica

Pregabalin Doesn’t Cut Intensity of Sciatica-Linked Leg Pain

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No significant difference in leg-pain intensity score at week eight or 52 for pregabalin, placebo
Pregabalin is beneficial for neuropathic pain

Pregabalin Benefits Not Linked to Prior Gabapentin Use

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Same relief for those who had/had not received gabapentin
Pregabalin significantly improves neuropathic pain

Pregabalin Significantly Improves Neuropathic Pain

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Pregabalin-linked improvement in pain seen regardless of time since pain onset
The widely prescribed drug pregabalin (Lyrica) may slightly increase the risk for birth defects

Pregabalin in Pregnancy Linked to Increased Risk of Birth Defects

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Defects include cardiac defects, structural anomalies in the central nervous system or other organs