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U.S. Food and Drug Administration approval of the kinase inhibitor regorafenib has been expanded to include hepatocellular carcinoma

Regorafenib Approved for Hepatocellular Carcinoma

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It is the first approved treatment for HCC in almost a decade
For patients with end-stage renal disease

Post-RFA Mortality Up for ESRD Patients Who Receive Dialysis

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Dialyzed patients have higher in-hospital mortality, hemorrhagic complications after RFA for HCC
Outreach strategies increase the percentage of patients with cirrhosis who undergo hepatocellular carcinoma screening

Outreach Strategies Increase HCC Screening in Cirrhosis

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No difference in proportion undergoing screening with mailed invitation with or without navigation
For patients with advanced unresectable hepatocellular carcinoma

Sorafenib Effect on HCC Survival Depends on Hepatitis Status

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Findings in meta-analysis of individual patient data for advanced unresectable hepatocellular carcinoma
For hepatitis C virus-infected patients

Diabetes Ups Risk of HCC, Death in Patients With Hepatitis C

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Diabetes increases risk of hepatocellular carcinoma development in patients with HCV
Outreach programs can increase hepatocellular carcinoma screening rates among patients with documented or suspected cirrhosis

Outreach Strategies Can Up HCC Screening in Cirrhosis

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More patients undergo screening when they receive mailed invitations for screening examination
Serum liver-type fatty acid binding protein early (day one) or late (day three to five) levels are associated with mortality in patients with acetaminophen-induced acute liver failure

In Acetaminophen-Induced Acute Liver Failure, FABP1 IDs Mortality

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Serum liver-type fatty acid binding protein can discriminate survivors from non-survivors
Insulin resistance assessed by homeostasis model assessment index correlates with the risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection

HOMA2-IR Tied to Hepatocellular Carcinoma Risk in Hepatitis B

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HOMA2-IR independently linked to HCC in patients without overt metabolic abnormalities
Weight loss following chemically-induced carcinogenesis is not beneficial for colon and liver carcinogenesis in a mouse model that mimics human obesity

Weight Loss May Not Benefit Colon, Liver Cancer

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In experimental study, no impact on colon tumorigenesis; may negatively impact liver repair
Having a large waistline

High BMI, Large Waist, T2DM Tied to Increased Odds of Liver Cancer

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Study adds support to liver cancer as an obesity-associated cancer