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'Liquid biopsy' technology holds promise for diagnosing

‘Liquid Biopsy’ Shows Promise for Hepatocellular Carcinoma

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DNA methylation markers show effectiveness for diagnosis and predicting prognosis
Causes of primary liver cancer differ widely among populations globally

Liver Cancer Remains a Major Public Health Burden Globally

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Findings can be used to guide liver cancer prevention efforts
Rates of major upper abdominal cancer resections in octogenarians are increasing

Upper Abdominal Cancer Resections Up in Octogenarians

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Increase in resection rates driven by trends in hepatic and pancreatic resections
For patients undergoing liver surgery

Extended Thromboprophylaxis Safe, Effective After Liver Surgery

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Severe complication rate 5.6 percent, with no 90-day mortalities
Telomere attrition occurs in tumor cells from patients with hepatocellular carcinoma (HCC)

Telomere Length Prognostic in Hepatocellular Carcinoma

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Shortened telomeres in tumor cells, CA-associated fibroblasts tied to reduced survival, upped recurrence
For patients with chronic hepatitis B

Subcirrhotic Liver Stiffness Cuts HCC Risk in Hepatitis B

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Achievement of subcirrhotic range of liver stiffness with antiviral therapy reduces HCC risk
For Caucasian patients with chronic hepatitis B

HCC Drops Beyond Five Years of Entecavir/Tenofovir Tx for Hep B

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Older age, lower platelets at baseline and year five, liver stiffness ≥12 kPa linked to HCC development
For patients with a primary diagnosis of hepatocellular cancer

Imaging of Pelvis Has Limited Value in Hepatocellular Cancer

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More than 80 percent of patients had no findings on MRI or CT; findings rarely linked to metastatic dz
Liver cancer is the fastest-growing cause of cancer deaths in the United States

Liver Cancer the Fastest-Growing Cause of Cancer Deaths in U.S.

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Substantial disparity seen in mortality rates for race/ethnicity and state of residence
Fluorescence in situ hybridization is associated with increased sensitivity compared with brush cytology for diagnosing cholangiocarcinoma in indeterminate biliary strictures

FISH Beneficial for Diagnosing Cholangiocarcinoma

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FISH increased sensitivity of brush cytology for cholangiocarcinoma while preserving specificity