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FDA: Common Diabetes Drug Januvia May Contain Traces of Carcinogen

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Nitroso-STG-19 has been found in some samples of the drug

For patients with type 2 diabetes

Sitagliptin Stimulates Distal Tubular Natriuresis in T2DM

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Increase in intact plasma SDF-1α1-67 and decrease in truncated plasma SDF-1α3-67
Sitagliptin has a neutral effect on cardiovascular risk among older patients with type 2 diabetes

Sitagliptin Has Neutral CV Risk Effect in Elderly With T2DM, CVD

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Neutral effects on cardiovascular risk among older patients with well-controlled T2DM and CVD
Patients with diabetes often have fractures

Sitagliptin Not Linked to Higher Fracture Risk in Diabetes

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Findings from TECOS trial show increased and decreased fracture risk with insulin, metformin
For patients with new-onset diabetic ketoacidosis and severe hyperglycemia

Metformin, Sitagliptin Prolong Normoglycemia Remission in DKA

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Findings in African-American patients with new-onset diabetic ketoacidosis and severe hyperglycemia
The dipeptidyl peptidase-4 inhibitors vildagliptin and sitagliptin have similar effects on incretin hormone secretion

Vildagliptin, Sitagliptin Have Similar Effects on Incretin

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Inter-individual variability seen in L-cell feedback induced by DPP-4 inhibitors
Use of saxagliptin or sitagliptin is not associated with increased risk of hospitalized heart failure compared with other antihyperglycemic agents

Saxagliptin, Sitagliptin Don’t Up Hospitalized Heart Failure

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No increased risk for new users of saxagliptin, sitagliptin versus other antihyperglycemic agents
For patients with diabetes and cardiovascular disease

ADA: Sitagliptin Shows No Major Adverse CV Effects in T2DM, CVD

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Findings among patients with type 2 diabetes and established cardiovascular disease