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For hospitalized patients with diabetes

Premixed Insulin Ups Hypoglycemia in Inpatients

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Similar glycemic control as basal-bolus regimen but elevated frequency of hypoglycemia
For patients with type 2 diabetes mellitus treated with metformin

Add-On Sitagliptin Cuts Risk of Insulin Initiation in T2DM

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Risk of insulin initiation lower for sitagliptin versus sulphonylurea as add-on to metformin
A closed-loop insulin delivery system can improve glucose control and reduce hypoglycemia in patients with type 1 diabetes

Positive Results for Home Use of Closed-Loop Insulin System

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Positive findings for 12-week use of closed-loop system compared with sensor-augmented pump therapy
Overweight and obese adolescents have persistently higher homeostasis model assessment of insulin resistance

Sleep Affects HOMA-IR in Overweight, Obese Teens

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Significant contributors include BMI z-score, age, pubertal stage, total sleep time, sleep efficiency
For patients with type 2 diabetes

Long-Acting Analog Insulin Doesn’t Up AMI Risk in T2DM

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No significant difference in risk for long-acting analog, other basal insulin therapies
A higher homeostatic model assessment-insulin resistance index score may be an early marker for an increased risk of cognitive decline in women

Insulin Resistance Tied to Signs of Cognitive Decline in Women

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Specifically, higher HOMA-IR score associated with poorer verbal fluency in women, but not in men
For individuals with type 1 diabetes

Long-Term Insulin Pump Use Reduces Mortality in T1DM

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Long-term use of insulin pump reduces fatal coronary heart disease, CVD, all-cause mortality
Hippocampal insulin resistance may be a key mediator of cognitive deficits

Hippocampal Insulin Resistance Linked to Neuroplasticity

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Rat model with hippocampal-specific insulin resistance downregulates insulin receptor expression
A microneedle-array patch ("smart insulin patch") containing glucose-responsive vesicles

‘Smart Insulin Patch’ Holds Promise for T1DM

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Patch contains glucose-regulated vesicles, which are loaded with insulin, sensitive to hypoxia
Serum 25-hydroxyvitamin D3 is associated with glucose-stimulated insulin secretion and β-cell function in individuals with newly diagnosed type 2 diabetes

Low Serum 25(OH)D3 in Patients Newly Diagnosed With T2DM

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Serum 25(OH)D3 linked to glucose-stimulated insulin secretion, β-cell function