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Liraglutide added to capped insulin is associated with reductions in glycated hemoglobin

Liraglutide Added to Capped Insulin Reduces Hemoglobin A1c

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Liraglutide also significantly reduces mean body weight, daily insulin dose; increases quality of life
Inhibiting the sympathetic nervous system by renal denervation improves insulin sensitivity in obese canines

Renal Denervation Ups Insulin Sensitivity in Preclinical Model

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Bilateral renal denervation completely normalizes hepatic insulin sensitivity in obese canines
C-peptide responses to mixed-meal tolerance tests are reliable surrogates of insulin secretion

C-Peptide Responses Reliable Surrogates of Insulin Secretion

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Expected inverse relationships between C-peptide and HbA1c, insulin dose vary over time, with age
Two novel loci have been identified that are associated with insulin sensitivity

Study IDs Two Novel Loci Linked to Insulin Sensitivity

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Associations for BCL2 and FAM19A2 were independent of known cardiometabolic loci
For East Asian patients with type 2 diabetes

50 Percent Insulin Lispro/Insulin Lispro Protamine Efficacious

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More effective than LM25 in certain dietary conditions, including with increased carbohydrate
Dulaglutide and glargine in combination with prandial lispro are associated with a similar percentage of time spent in the normoglycemic range

Dulaglutide, Glargine Plus Lispro Improve Glycemic Control

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Dulaglutide and glargine plus lispro result in similar proportion of glucose values in normoglycemic range
A multi-interventional approach can reduce preventable hypoglycemic events in hospitalized pediatric patients receiving insulin

Intervention Combination Can Cut Pediatric Hypoglycemic Events

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Approach can reduce preventable hypoglycemic events in hospitalized children receiving insulin
For overweight and obese subjects

Trans-Resveratrol, Hesperetin Up Glo1 Expression, Metabolic Health

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tRES-HESP coformulation linked to improvements in metabolic and vascular health
The price of insulin has tripled in only 10 years

Cost of Insulin Found to Have Tripled Over Past Decade

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Since 2010, per-person costs topped spending on all other diabetes drugs combined
For individuals with type 1 diabetes

More Variability in Overnight Insulin Requirements in T1DM

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Overnight insulin requirements significantly more variable than daytime, total daily insulin needs