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Intranasal insulin application appears to be safe

No Safety Concerns Noted in Study of Intranasal Insulin Use

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However, more data is needed on the long-term safety of chronic intranasal insulin administration
After induction short-term intensive insulin therapy (IIT)

Metformin After Induction Tx May Preserve Beta-Cell Function

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Also associated with better glycemic control than repeat intensive insulin therapy after induction IIT
A targeted microbiome intervention

Microbiome Intervention With Niacin Aids Insulin Sensitivity

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Delayed-release microcapsules of nicotinic acid induce favorable microbiome changes
Stricter glycemic control during short-term intensive insulin therapy for newly diagnosed type 2 diabetes patients is associated with a higher likelihood of remission at one year

Stricter Short-Term Glycemic Control May Increase Remission

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Findings among newly diagnosed diabetes patients undergoing short-term intensive insulin therapy
Oral insulin does not delay onset of type 1 diabetes in autoantibody-positive relatives of patients with type 1 diabetes

Insulin Doesn’t Prevent Diabetes in Relatives of T1DM Patients

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Oral insulin doesn't delay onset in autoantibody-positive relatives of patients with type 1 diabetes
For young patients with type 1 diabetes

Better Glycemic Control With Insulin Pump for Youth With T1D

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Severe hypoglycemia, diabetic ketoacidosis less likely with insulin pump therapy than injection therapy
Cardiometabolic risk and homeostatic model assessment of insulin resistance increase with increasing body mass index categories among children

Cardiometabolic Risk, HOMA-IR Up With Increasing BMI in Young

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Cardiorespiratory fitness cuts cardiometabolic risk score as BMI categories rise in children
Cardiovascular outcomes in patients with diabetes are not explained by insulin resistance

Insulin Dose Not Tied to Cardiovascular Outcomes

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Similar findings among individuals with diabetes able to achieve normoglycemia
Intestinal glucose stimulation has an anti-incretin effect

Intestinal Glucose Stimulation Has Anti-Incretin Effect

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Insulin sensitivity lower during oral versus IV glucose administration; difference amplified in obese
A cognitive test involving animal name recall can predict which elderly patients succeed in mastering an insulin self-injection technique within one week

Cognitive Test Predicts Elderly Insulin Injection Success

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Number of animal names recalled in one minute was the most useful indicator